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Given the safety profile and nonsteroidal mechanism of pimecrolimus, there has been significant interest in its use in the treatment of a variety of dermatological conditions. This article reviews research that has been published on the off-label uses of topical pimecrolimus, with a focus on published RCTs. Convincing evidence exists supporting pimecrolimus\u2019 efficacy in oral lichen planus and seborrheic dermatitis. For other conditions studied to date, pimecrolimus may prove to be a useful treatment alternative when conventional agents fail. Adverse events seen with its off-label use were typically application site reactions, the most common being a transient burning sensation. In summary, pimecrolimus appears to be an effective agent in the treatment of multiple dermatological conditions and may be worth considering as a pharmacologic alternative in several conditions when first-line treatment fails, or for areas that are more susceptible to the adverse effects of topical corticosteroids.<\/jats:p>","DOI":"10.1177\/1203475419847950","type":"journal-article","created":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T09:08:52Z","timestamp":1557133732000},"page":"442-448","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Off-label Uses of Topical Pimecrolimus"],"prefix":"10.1177","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5128-2488","authenticated-orcid":false,"given":"Matthew","family":"Ladda","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Toronto, ON, 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