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Topical calcineurin inhibitors are approved for the treatment of eczema, and their anti-inflammatory, immunomodulatory, and steroid-sparing effects make them an attractive therapeutic option for a wide variety of other dermatologic diseases. This review summarizes and qualifies the available evidence supporting the clinical effectiveness of tacrolimus ointment and pimecrolimus cream in non-eczema indications. There is high-quality evidence supporting the effectiveness of topical calcineurin inhibitors in multiple dermatological disorders including vitiligo; psoriasis of the face, folds, and genitals; seborrheic dermatitis; chronic hand dermatitis; contact dermatitis; oral lichen planus; lichen sclerosus; morphea; and cutaneous lupus erythematosus. Lower-quality evidence suggests they may be considered as an option in many other cutaneous disorders.<\/jats:p>","DOI":"10.1177\/1203475419857668","type":"journal-article","created":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T03:10:46Z","timestamp":1567480246000},"page":"27S-34S","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":53,"title":["Off-Label Use of Topical Calcineurin Inhibitors in Dermatologic Disorders"],"prefix":"10.1177","volume":"23","author":[{"given":"Lyn","family":"Guenther","sequence":"first","affiliation":[{"name":"Western University, London, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Lynde","sequence":"additional","affiliation":[{"name":"Lynde Dermatology, Probity Medical Research, Markham, ON, and Department of Medicine, University of Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Poulin","sequence":"additional","affiliation":[{"name":"Laval University and Centre dermatologique du Qu\u00e9bec m\u00e9tropolitain and Centre de Recherche Dermatologique du Qu\u00e9bec m\u00e9tropolitain, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,9,3]]},"reference":[{"key":"bibr1-1203475419857668","doi-asserted-by":"publisher","DOI":"10.1097\/01206501-200503000-00003"},{"key":"bibr2-1203475419857668","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.7.14.1967"},{"key":"bibr3-1203475419857668","unstructured":"Hengge UR, ed. 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