{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T02:12:36Z","timestamp":1777515156445,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T00:00:00Z","timestamp":1564963200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Med Surg"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background and objective<\/jats:title>\n                    <jats:p>East Asians exposed to the urate-lowering drug allopurinol have a predilection for severe cutaneous drug reactions such as drug-induced hypersensitivity syndrome or drug reaction with eosinophilia and systemic symptoms (DRESS) and Stevens-Johnson syndrome\/toxic epidermal necrolysis (SJS\/TEN). Screening is recommended in patients of East Asian descent for the presence of HLA-B*58:01 prior to allopurinol initiation to avoid these complications. Utilization rates of the HLA-B*58:01 predictive screening test within the Greater Vancouver area, which has a population composed of 40.1% people of East Asian descent, are unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measures<\/jats:title>\n                    <jats:p>We identified cases of DRESS or SJS\/TEN due to allopurinol using the Vancouver General Hospital dermatology consult service database. We next compared the frequency in which the HLA-B*58:01 screening test was ordered since 2012 to the estimated frequency of new prescriptions for allopurinol prescribed for the management of gout among the East Asians.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We report 5 cases of East Asian patients exposed to allopurinol for management of gout between 2012 and 2016, who developed DRESS (4 patients) or SJS\/TEN (1 patient). All were of HLA-B*58:01 genotype, representing preventable cases. The HLA-B*58:01 test was ordered 6 times in 2012, whereas the estimated number of new cases of allopurinol-prescribed gout among patients of East Asian descent during that time period was 13. For 2012, testing was ordered for only 46% of at-risk patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We continue to observe cases of severe cutaneous drug reactions among high-risk individuals due to allopurinol exposure. The HLA-B*58:01 screening test for allopurinol hypersensitivity is underutilized in our geographic area.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1203475419867599","type":"journal-article","created":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T03:32:10Z","timestamp":1564975930000},"page":"595-601","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["<i>HLA-B*58:01<\/i>\n                    Genotyping to Prevent Cases of DRESS and SJS\/TEN in East Asians Treated with Allopurinol\u2014A Canadian Missed Opportunity"],"prefix":"10.1177","volume":"23","author":[{"given":"Marisa Grace","family":"Ponzo","sequence":"first","affiliation":[{"name":"Department of Dermatology and Skin Science, University of British Columbia, Vancouver, BC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Miliszewski","sequence":"additional","affiliation":[{"name":"Division of Dermatology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark G.","family":"Kirchhof","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine, University of Ottawa and the Ottawa Hospital, Ottawa, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul A.","family":"Keown","sequence":"additional","affiliation":[{"name":"Vancouver General Hospital, Vancouver, BC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan P.","family":"Dutz","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Skin Science, University of British Columbia, Vancouver, BC, Canada"},{"name":"BC Children\u2019s Hospital Research Institute, Vancouver, BC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,8,5]]},"reference":[{"key":"bibr1-1203475419867599","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2015.3546"},{"key":"bibr2-1203475419867599","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2016.10.009"},{"key":"bibr3-1203475419867599","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.01.032"},{"key":"bibr4-1203475419867599","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.05.002"},{"key":"bibr5-1203475419867599","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0409500102"},{"key":"bibr6-1203475419867599","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21772"},{"key":"bibr7-1203475419867599","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21773"},{"key":"bibr8-1203475419867599","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07704.x"},{"key":"bibr9-1203475419867599","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2000.00061.x"},{"key":"bibr10-1203475419867599","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-200205000-00015"},{"key":"bibr11-1203475419867599","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp030733"},{"key":"bibr12-1203475419867599","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.290.6486.1969"},{"key":"bibr13-1203475419867599","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2012.209"},{"key":"bibr14-1203475419867599","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.161"},{"key":"bibr15-1203475419867599","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.151476"},{"key":"bibr16-1203475419867599","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22409"},{"key":"bibr17-1203475419867599","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.120803"},{"key":"bibr18-1203475419867599","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h4848"}],"container-title":["Journal of Cutaneous Medicine and Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1203475419867599","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1203475419867599","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1203475419867599","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:54:19Z","timestamp":1777391659000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1203475419867599"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,5]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1177\/1203475419867599"],"URL":"https:\/\/doi.org\/10.1177\/1203475419867599","relation":{},"ISSN":["1203-4754","1615-7109"],"issn-type":[{"value":"1203-4754","type":"print"},{"value":"1615-7109","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,5]]}}}