{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T20:13:01Z","timestamp":1789243981230,"version":"build-2803163510"},"reference-count":24,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2020,3,5]],"date-time":"2020-03-05T00:00:00Z","timestamp":1583366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Med Surg"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:p>Crisaborole, a topical phosphodiesterase-4 inhibitor, was recently approved in 2016 for the treatment of mild to moderate atopic dermatitis in adults and children greater than 2 years of age. Since that time, several case reports and a small randomized controlled trial have been published regarding the off-label use of crisaborole for the treatment of other inflammatory dermatologic disorders. This paper reviews the current, albeit limited, evidence for off-label use of crisaborole for psoriasis, seborrheic dermatitis, vitiligo, and inflammatory linear verrucous epidermal nevus. Additional potential therapeutic uses for crisaborole are also postulated, based on its mechanism of action. Future studies are required to elucidate the full therapeutic potential of crisaborole; however, it is a welcome addition to the current nonsteroid topical treatments for inflammatory dermatologic disease.<\/jats:p>","DOI":"10.1177\/1203475420909794","type":"journal-article","created":{"date-parts":[[2020,3,5]],"date-time":"2020-03-05T07:41:24Z","timestamp":1583394084000},"page":"292-296","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Off-Label Therapeutic Potential of Crisaborole"],"prefix":"10.1177","volume":"24","author":[{"given":"Caitlyn","family":"Makins","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of British Columbia, Kelowna, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravina","family":"Sanghera","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, University of Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9296-5851","authenticated-orcid":false,"given":"Parbeer S.","family":"Grewal","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine, University of Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,3,5]]},"reference":[{"issue":"4","key":"bibr1-1203475420909794","first-page":"390","volume":"15","author":"Jarnagin K.","year":"2016","journal-title":"J Drugs Dermatol"},{"key":"bibr2-1203475420909794","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.116.232819"},{"key":"bibr3-1203475420909794","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.06.010"},{"key":"bibr4-1203475420909794","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-016-0204-6"},{"key":"bibr5-1203475420909794","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.03.049"},{"key":"bibr6-1203475420909794","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.06.1288"},{"key":"bibr7-1203475420909794","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2018.1480747"},{"key":"bibr8-1203475420909794","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2018.2397"},{"issue":"1","key":"bibr9-1203475420909794","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jaad.2016.02.1164","volume":"75","author":"Bissonnette R.","year":"2016","journal-title":"J Am Acad Dermatol"},{"key":"bibr10-1203475420909794","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14647"},{"key":"bibr11-1203475420909794","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04082.x"},{"key":"bibr12-1203475420909794","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.1996.tb00131.x"},{"issue":"5","key":"bibr13-1203475420909794","first-page":"577","volume":"17","author":"Liu D.","year":"2018","journal-title":"J Drugs Dermatol"},{"key":"bibr14-1203475420909794","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.463"},{"key":"bibr15-1203475420909794","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3007811"},{"key":"bibr16-1203475420909794","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.12256"},{"key":"bibr17-1203475420909794","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.09.004"},{"key":"bibr18-1203475420909794","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14356"},{"key":"bibr19-1203475420909794","doi-asserted-by":"publisher","DOI":"10.3109\/09546630903266761"},{"key":"bibr20-1203475420909794","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10351.x"},{"key":"bibr21-1203475420909794","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12923"},{"key":"bibr22-1203475420909794","doi-asserted-by":"publisher","DOI":"10.25251\/skin.3.2.47"},{"key":"bibr23-1203475420909794","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-200109000-00011"},{"key":"bibr24-1203475420909794","doi-asserted-by":"publisher","DOI":"10.1111\/pde.13793"}],"container-title":["Journal of Cutaneous Medicine and Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1203475420909794","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1203475420909794","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1203475420909794","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:54:24Z","timestamp":1777391664000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1203475420909794"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,5]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["10.1177\/1203475420909794"],"URL":"https:\/\/doi.org\/10.1177\/1203475420909794","relation":{},"ISSN":["1203-4754","1615-7109"],"issn-type":[{"value":"1203-4754","type":"print"},{"value":"1615-7109","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,5]]}}}