{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:07:35Z","timestamp":1791655655455,"version":"4.3.4"},"reference-count":55,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T00:00:00Z","timestamp":1599696000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"University of Toronto Department of Medicine Summer Research Scholarships"},{"name":"Innovation Fund of the Alternate Funding Plan for the Academic Health Sciences Centers of Ontario"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Med Surg"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Treatment practices vary for lentigo maligna (LM). Staged excision with circumferential margin control (SECMC) has the potential to achieve low recurrence rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the clinical outcomes of SECMC using permanent, paraffin-embedded sections and delayed reconstruction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective, uncontrolled, observational cohort study involving patients who underwent staged excision for LM of the head and neck at Women\u2019s College Hospital in Toronto, Canada, from September 2010 to March 2013. Recurrence and infection rates were ascertained from patient charts and postal surveys.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>One hundred and two patients (45 female, 57 male) were included with a median follow-up time of 1410.5 (IQR 260-1756) days. The median age was 69 (IQR 61-79) years. Approximately one-fifth (21%, 21\/102) of patients required greater than 0.5 cm margins to achieve histological clearance. One patient (1\/102) upstaged to invasive melanoma based on the initial stage of excision. The infection rate was 6% (6\/102) and the 5-year cumulative recurrence rate was 1.4% (95% CI 0.2-9.6%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SECMC using permanent sections and delayed reconstruction appears to be a safe and effective treatment method for LM on the head and neck. Randomized trials are needed to help define the optimal treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1203475420952425","type":"journal-article","created":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T01:04:26Z","timestamp":1599786266000},"page":"18-24","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Outcomes of Staged Excision With Circumferential en Face Margin Control for Lentigo Maligna of the Head and Neck"],"prefix":"10.1177","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5237-4878","authenticated-orcid":false,"given":"Annie","family":"Liu","sequence":"first","affiliation":[{"name":"Division of Dermatology, Women\u2019s College Hospital, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Botkin","sequence":"additional","affiliation":[{"name":"Division of Dermatology, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Murray","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Women\u2019s College Hospital, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nowell","family":"Solish","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Women\u2019s College Hospital, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Kitchen","sequence":"additional","affiliation":[{"name":"Women\u2019s College Research Institute, Women\u2019s College Hospital, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An-Wen","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Women\u2019s College Hospital, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,9,10]]},"reference":[{"key":"bibr1-1203475420952425","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2005.23852.x"},{"key":"bibr2-1203475420952425","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0000000000000092"},{"key":"bibr3-1203475420952425","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.06.014"},{"key":"bibr4-1203475420952425","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-005-3637-4"},{"key":"bibr5-1203475420952425","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.12928"},{"key":"bibr6-1203475420952425","volume-title":"Cancer Facts and Figures 2010","author":"Cancer Society A","year":"2010"},{"key":"bibr7-1203475420952425","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.09.018"},{"issue":"18","key":"bibr8-1203475420952425","volume":"0190","author":"Fix W.","year":"2018","journal-title":"J Am Acad Dermatol"},{"key":"bibr9-1203475420952425","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.10.049"},{"key":"bibr10-1203475420952425","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001498"},{"key":"bibr11-1203475420952425","first-page":"CD010308","volume":"12","author":"Tzellos T.","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr12-1203475420952425","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdv297"},{"key":"bibr13-1203475420952425","unstructured":"Dummer R., Keilholz U. eUpdate \u2013 Cutaneous Melanoma Algorithms. 2016. 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