{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T01:46:36Z","timestamp":1777513596904,"version":"3.51.4"},"reference-count":39,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T00:00:00Z","timestamp":1643328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Med Surg"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Identification of culprit drugs when managing cutaneous drug eruptions is essential. Causality assessment methods (CAMs) have been proposed, including lab-based techniques. However, no consensus guidelines exist.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To identify and map the functionality and feasibility of lab-based CAMs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A scoping review was conducted to identify culprit drug identification methods. Publications on lab-based methods were analyzed. Medline, Embase, and Cochrane Central Register of Controlled Trials databases were searched.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty-five publications met inclusion criteria. Nine lab-based CAMs were studied, including lymphocyte transformation test, cytokine measurement (ELISpot, ELISA, beads array assay), modified IFN-\u0263 ELISpot, CellScan, histamine release, granzyme B-ELISpot, intracellular granulysin, lymphocyte toxicity assay, and HLA allele genotyping. Diagnostic accuracy was reported for 8\/9 methods. Clinical assessment and operational algorithms were commonly used as validation benchmarks. Lab-based methods were assessed at different phases of a drug eruption including in the acute (18.1%), recovery (27.3%), acute and recovery (27.3%), or an unspecified phase (27.3%). Lymphocyte transformation test (specificity 30% to 100%, sensitivity 27% to 73%) and cytokine measurement (specificity 76% to 100%, sensitivity 20% to 84%) were the most common methods studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Lab-based CAMs can be low-risk, effective, and complementary of clinical methods. High-quality studies are needed to adequately develop and validate these tools for clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/12034754211073667","type":"journal-article","created":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T04:29:26Z","timestamp":1643344166000},"page":"291-296","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Lab-Based Culprit Drug Identification Methods for Cutaneous Drug Eruptions: A Scoping Review"],"prefix":"10.1177","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3363-3587","authenticated-orcid":false,"given":"Reetesh","family":"Bose","sequence":"first","affiliation":[{"name":"Division of Dermatology, University of Ottawa, ON, Canada"},{"name":"Division of Dermatology, The Ottawa Hospital, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0499-4930","authenticated-orcid":false,"given":"Alexandra","family":"Finstad","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Ottawa, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selam","family":"Ogbalidet","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Ottawa, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mina","family":"Boshra","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Ottawa, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Fahim","sequence":"additional","affiliation":[{"name":"Division of Dermatology, University of Ottawa, ON, Canada"},{"name":"Division of Dermatology, The Ottawa Hospital, Canada"},{"name":"Faculty of Medicine, University of Ottawa, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,1,28]]},"reference":[{"key":"bibr1-12034754211073667","doi-asserted-by":"publisher","DOI":"10.5414\/ALX01508E"},{"key":"bibr2-12034754211073667","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30378-6"},{"key":"bibr3-12034754211073667","doi-asserted-by":"publisher","DOI":"10.1111\/all.12350"},{"issue":"10","key":"bibr4-12034754211073667","first-page":"194","volume":"10","author":"Zhao J.","year":"2017","journal-title":"Drug Saf"},{"key":"bibr5-12034754211073667","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200831010-00003"},{"key":"bibr6-12034754211073667","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1138"},{"key":"bibr7-12034754211073667","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200629080-00006"},{"issue":"3","key":"bibr8-12034754211073667","first-page":"111","volume":"5","author":"Kotrulja L.","year":"1997","journal-title":"Acta Dermatovenerologica Croat"},{"key":"bibr9-12034754211073667","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12145"},{"key":"bibr10-12034754211073667","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2018.05.004"},{"key":"bibr11-12034754211073667","doi-asserted-by":"publisher","DOI":"10.7326\/M18-0850"},{"key":"bibr12-12034754211073667","doi-asserted-by":"publisher","DOI":"10.2165\/11537780-000000000-00000"},{"key":"bibr13-12034754211073667","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1993.01680220104023"},{"key":"bibr14-12034754211073667","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.8.1019"},{"key":"bibr15-12034754211073667","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1995.01690170041005"},{"key":"bibr16-12034754211073667","volume-title":"Covidence systematic review software, Veritas Health Innovation","author":"Innovation VH","year":"2020"},{"key":"bibr17-12034754211073667","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2017.03.007"},{"key":"bibr18-12034754211073667","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0143"},{"key":"bibr19-12034754211073667","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01553.x"},{"key":"bibr20-12034754211073667","doi-asserted-by":"publisher","DOI":"10.1159\/000448284"},{"key":"bibr21-12034754211073667","doi-asserted-by":"publisher","DOI":"10.1111\/cea.13076"},{"key":"bibr22-12034754211073667","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/687532"},{"key":"bibr23-12034754211073667","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1994.178"},{"key":"bibr24-12034754211073667","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2010.01000.x"},{"key":"bibr25-12034754211073667","doi-asserted-by":"publisher","DOI":"10.1080\/10446670410001722230"},{"key":"bibr26-12034754211073667","doi-asserted-by":"publisher","DOI":"10.1016\/j.mpmed.2017.04.001"},{"key":"bibr27-12034754211073667","doi-asserted-by":"publisher","DOI":"10.2174\/1381612825666191107104126"},{"issue":"1","key":"bibr28-12034754211073667","first-page":"15","volume":"42","author":"Sharma VK.","year":"1996","journal-title":"J Postgrad Med"},{"key":"bibr29-12034754211073667","doi-asserted-by":"publisher","DOI":"10.2174\/1381612825666191107105440"},{"issue":"6","key":"bibr30-12034754211073667","first-page":"219","volume":"37","author":"Aberer W","year":"2005","journal-title":"Eur Ann Allergy Clin Immunol"},{"key":"bibr31-12034754211073667","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e32834a974c"},{"key":"bibr32-12034754211073667","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2001.450601.x"},{"issue":"7","key":"bibr33-12034754211073667","first-page":"625","volume":"13","author":"Paulmann M.","year":"2015","journal-title":"J Dtsch Dermatol Ges"},{"key":"bibr34-12034754211073667","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-018-0793-7"},{"key":"bibr35-12034754211073667","doi-asserted-by":"publisher","DOI":"10.1177\/1203475417746148"},{"key":"bibr36-12034754211073667","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-015-0158-0"},{"key":"bibr37-12034754211073667","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0000000000000546"},{"key":"bibr38-12034754211073667","doi-asserted-by":"publisher","DOI":"10.18176\/jiaci.0480"},{"key":"bibr39-12034754211073667","doi-asserted-by":"publisher","DOI":"10.1093\/jamia\/ocv127"}],"container-title":["Journal of Cutaneous Medicine and Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/12034754211073667","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/12034754211073667","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/12034754211073667","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:49:06Z","timestamp":1777391346000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/12034754211073667"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,28]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1177\/12034754211073667"],"URL":"https:\/\/doi.org\/10.1177\/12034754211073667","relation":{},"ISSN":["1203-4754","1615-7109"],"issn-type":[{"value":"1203-4754","type":"print"},{"value":"1615-7109","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,28]]}}}