{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T01:47:22Z","timestamp":1777513642626,"version":"3.51.4"},"reference-count":43,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T00:00:00Z","timestamp":1647907200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Med Surg"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>While biologic therapies revolutionized treatment of immune-mediated inflammatory diseases (IMIDs), some adverse effects have been noted. This includes the development and exacerbation of PsA in patients on biologic agents, however the outcomes were not extensively explored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To perform a systematic review to characterize the outcomes of PsA onset or exacerbation secondary to biologic use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>MEDLINE and EMBASE search conducted on March 23, 2021 resulted in 18 studies comprised of 64 patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 64 patients, 57 (89.1%) experienced new-onset PsA and 7 (10.9%) experienced exacerbation of preexisting PsA following exposure to a biologic; most commonly a TNF-\u03b1 inhibitor (42.2%, n = 27\/64) and IL-12\/23 inhibitors (39.1%, n = 25\/64). The mean durations of biologic use before PsA onset and exacerbation were 14.8 months and 5.2 months, respectively. Twenty-four patients (44.4%) subsequently switched to an alternate biologic without further reports of PsA-related adverse events. All 64 patients reported a specific treatment for PsA; most commonly discontinuation of the associated biologic agent (32.8%, n = 21\/64). Complete resolution of PsA was reported in 35.9% ( n = 23\/64) of cases, of which 91.3% ( n = 21\/23) resulted after discontinuation of biologic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although we characterized outcomes of PsA induction and exacerbation secondary to biologic use, large-scale studies are required.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/12034754221088556","type":"journal-article","created":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T21:30:10Z","timestamp":1647984610000},"page":"414-419","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["A Systematic Review Characterizing Psoriatic Arthritis Onset and Exacerbation in Patients Receiving Biologic Therapy"],"prefix":"10.1177","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2252-5663","authenticated-orcid":false,"given":"Muskaan","family":"Sachdeva","sequence":"first","affiliation":[{"name":"Temerty Faculty of Medicine, University of Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abrahim","family":"Abduelmula","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Western University, London, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3514-9513","authenticated-orcid":false,"given":"Asfandyar","family":"Mufti","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine, University of Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6844-2724","authenticated-orcid":false,"given":"Jorge R.","family":"Georgakopoulos","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine, University of Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1805-9994","authenticated-orcid":false,"given":"Yuliya","family":"Lytvyn","sequence":"additional","affiliation":[{"name":"Temerty Faculty of Medicine, University of Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jensen","family":"Yeung","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine, University of Toronto, ON, Canada"},{"name":"Department of Dermatology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada"},{"name":"Department of Dermatology, Women\u2019s College Hospital, Toronto, ON, Canada"},{"name":"Probity Medical Research, Waterloo, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,3,22]]},"reference":[{"key":"bibr1-12034754221088556","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/9259646"},{"key":"bibr2-12034754221088556","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12802"},{"issue":"1","key":"bibr3-12034754221088556","first-page":"137","volume":"35","author":"Napolitano M.","year":"2017","journal-title":"Clin Exp Rheumatol"},{"key":"bibr4-12034754221088556","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2010.521811"},{"key":"bibr5-12034754221088556","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30830-4"},{"key":"bibr6-12034754221088556","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.080691"},{"key":"bibr7-12034754221088556","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.19144.1"},{"key":"bibr8-12034754221088556","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-015-0640-3"},{"key":"bibr9-12034754221088556","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2018.04.003"},{"key":"bibr10-12034754221088556","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"bibr11-12034754221088556","unstructured":"AM. 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