{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:46:56Z","timestamp":1787496416004,"version":"build-2736575974"},"reference-count":23,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2022,8,7]],"date-time":"2022-08-07T00:00:00Z","timestamp":1659830400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005565","name":"janssen biotech","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005565","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Med Surg"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Psoriasis is a chronic, immune-mediated inflammatory disease with an implied connection to psychiatric disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to illustrate an association between psoriasis and psychiatric disorders using real world data gathered from the Newfoundland and Labrador population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data on 15,100 patients with psoriasis and 75,500 controls (1:5) was collected from the Newfoundland and Labrador Centre for Health Information\u2019s Electronic Health Records. The cases and controls were matched for age, sex, and geography. Indicators for psychiatric disorders include diagnosis of mental illnesses from physician\u2019s visits and hospitalization records (all coded for mental health using ICD-9 and ICD-10 codes).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>9,991 (66.2%) cases were identified to have at least one visit with a diagnostic code for mental illness compared to 42,276 (56.0%), P &lt; .0001 in the control group. The percentage of people coded for anxiety was 36.50% compared to 28.95%, P &lt; .0001; depression was 37.04% compared to 30.19%, P &lt; .0001; and adjustment disorder was 6.89% versus 5.48%, P &lt; .0001, among those with and without psoriasis, respectively. The greatest risk for anxiety [OR 1.4 (1.20, 1.67)] and depression [OR 1.65 (1.36, 2.00)] among psoriasis patients was between the 0 to 20 age group. Women with psoriasis are more likely to have anxiety [OR 1.08 (1.03, 1.13)], depression [OR 1.04 (1.01, 1.09)] and adjustment disorder [OR 1.07 (0.98, 1.17)] compared to female controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our result shows that patients with psoriasis have an increased prevalence of mental illness. Using real world data to carry out further investigations will better elucidate this association and provide an increased understanding of the association between psoriasis and mental disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/12034754221117736","type":"journal-article","created":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T01:55:20Z","timestamp":1659923720000},"page":"494-501","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Real World Studies of Psoriasis and Mental Illness in Newfoundland and Labrador"],"prefix":"10.1177","volume":"26","author":[{"given":"Winifred","family":"Badaiki","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Memorial University of Newfoundland and Labrador, St. John\u2019s, Newfoundland and Labrador, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Penney","sequence":"additional","affiliation":[{"name":"Newlab Clinical Research, St. John\u2019s, Newfoundland and Labrador, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn","family":"Pyper","sequence":"additional","affiliation":[{"name":"Janssen Inc., Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kendra","family":"Lester","sequence":"additional","affiliation":[{"name":"The Newfoundland and Labrador Centre for Health Information, St. John\u2019s, Newfoundland and Labrador, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janelle","family":"Skeard","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Memorial University of Newfoundland and Labrador, St. John\u2019s, Newfoundland and Labrador, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janey","family":"Shin","sequence":"additional","affiliation":[{"name":"Janssen Inc., Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda","family":"Fisher","sequence":"additional","affiliation":[{"name":"Janssen Inc., Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Gulliver","sequence":"additional","affiliation":[{"name":"Newlab Clinical Research, St. John\u2019s, Newfoundland and Labrador, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne","family":"Gulliver","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Memorial University of Newfoundland and Labrador, St. John\u2019s, Newfoundland and Labrador, Canada"},{"name":"Newlab Clinical Research, St. John\u2019s, Newfoundland and Labrador, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4521-2029","authenticated-orcid":false,"given":"Proton","family":"Rahman","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Memorial University of Newfoundland and Labrador, St. John\u2019s, Newfoundland and Labrador, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,8,7]]},"reference":[{"key":"bibr1-12034754221117736","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.11.057"},{"key":"bibr2-12034754221117736","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20061475"},{"key":"bibr3-12034754221117736","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20153038"},{"key":"bibr4-12034754221117736","doi-asserted-by":"publisher","DOI":"10.1177\/1203475418791114"},{"key":"bibr5-12034754221117736","doi-asserted-by":"publisher","DOI":"10.1177\/1203475416650430"},{"key":"bibr6-12034754221117736","doi-asserted-by":"publisher","DOI":"10.2310\/7750.2010.10013"},{"key":"bibr7-12034754221117736","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2013.5015"},{"key":"bibr8-12034754221117736","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1993.tb02790.x"},{"key":"bibr9-12034754221117736","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2000.00085.x"},{"key":"bibr10-12034754221117736","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2017.03.008"},{"key":"bibr11-12034754221117736","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt-2018-000788"},{"issue":"2","key":"bibr12-12034754221117736","first-page":"15","volume":"4","author":"Miani C.","year":"2014","journal-title":"Rand Health Q"},{"key":"bibr13-12034754221117736","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsb1609216"},{"key":"bibr14-12034754221117736","unstructured":"Health Canada. 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