{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T01:47:58Z","timestamp":1777513678560,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T00:00:00Z","timestamp":1665100800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Med Surg"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To answer the following clinical research question: \u201cAmong patients with multiple basal cell carcinomas (mBCCs), can panoramic radiograph (PaR) facilitate the diagnosis of Gorlin-Goltz syndrome (GGS)?\u201d<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study enrolled mBCCs subjects who presented to a German tertiary care center between 1 January 2015 and 31 December 2021. The primary predictor was presence of syndromic mBCCs, and the main outcomes were jaw cysts and odontogenic keratocysts (OKCs). Descriptive, bi- and multivariate statistics, diagnostic test evaluation, and number needed to screen (NNS) were computed at \u03b1 = 95%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The sample comprised 527 mBCCs patients (36.1% females; 6.8% GGS; 5.5% OKCs; mean age, 74.5 \u00b1 15.8 years [range, 15-102]). There was a significant association between syndromic mBCCs and jaw cysts ( P &lt; .0001; NNS = 2 [95% CI, CI, 1.1 to 1.4]). In the adjusted logistic model, PaR identified GGS via radiographic diagnosis of jaw cysts in case of 1) age \u2264 35 years, 2) \u2265 5 BCCs, and 3) \u2265 1 high-risk BCCs. Nearly every jaw cyst identified by PaR was OKCs ( P = .01; 95% CI, 3.1 to 3,101.4; NNS = 1.3 [95% CI, .9 to 2]). The post hoc power was 100%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Dental screening with the use of PaR for mBCCs patients, especially those aged \u226435 years, or with \u22655 BCCs, or \u22651 high-risk BCCs, may be helpful in detection and identification of GGS through recognition of OKCs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/12034754221128798","type":"journal-article","created":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T05:01:02Z","timestamp":1665118862000},"page":"586-592","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Dental Screening Including Panoramic Radiograph for Gorlin-Goltz Syndrome in Patients With Multiple Basal Cell Carcinomas"],"prefix":"10.1177","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7427-3461","authenticated-orcid":false,"given":"Poramate","family":"Pitak-Arnnop","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Philipps-University of Marburg, and Department of Oral and Craniomaxillofacial Plastic Surgery, UKGM GmbH, University Hospital Marburg, Marburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Levyn Kay","family":"Witohendro","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Goethe University, Frankfurt am Main, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chatpong","family":"Tangmanee","sequence":"additional","affiliation":[{"name":"Department of Statistics, Chulalongkorn Business School, Chulalongkorn University, Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anonknart","family":"Bhakdinaronk","sequence":"additional","affiliation":[{"name":"Division of Oral and Maxillofacial Radiology, Department of Oral Diagnosis, Faculty of Dentistry, Naresuan University Phitsanulok, Phitsanulok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keskanya","family":"Subbalekha","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prim","family":"Auychai","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nattapong","family":"Sirintawat","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Mahidol University, Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Paul","family":"Meningaud","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive, Esthetic and Maxillofacial Surgery, Henri Mondor University Hospital, AP-HP, Faculty of Medicine, University Paris-Est Cr\u00e9teil Val de Marne (Paris XII), Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Neff","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Philipps-University of Marburg, and Department of Oral and Craniomaxillofacial Plastic Surgery, UKGM GmbH, University Hospital Marburg, Marburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,10,7]]},"reference":[{"key":"bibr1-12034754221128798","doi-asserted-by":"publisher","DOI":"10.1159\/000444792"},{"key":"bibr2-12034754221128798","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.756025"},{"key":"bibr3-12034754221128798","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-022-01414-z"},{"key":"bibr4-12034754221128798","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2009.10.006"},{"key":"bibr5-12034754221128798","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-016-0706-9"},{"key":"bibr6-12034754221128798","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2022.03.023"},{"key":"bibr7-12034754221128798","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.02385"},{"key":"bibr8-12034754221128798","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0262151"},{"key":"bibr9-12034754221128798","unstructured":"Die Arbeitsgemeinschaft Dermatologische Onkologie der Deutschen Krebsgesellschaft und der Deutschen Dermatologischen Gesellschaft (DDG), S2k-Leitlinie Basalzellkarzinom der Haut (Aktualisierung 2017\/18), 2018. 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