{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T04:29:53Z","timestamp":1780460993618,"version":"3.54.1"},"reference-count":23,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T00:00:00Z","timestamp":1670198400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Med Surg"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Merkel cell carcinoma (MCC) is a rare malignant cutaneous tumor with frequent metastases. They often appear in the face where cosmetic and functional outcome is critical. Mohs micrographic surgery (MMS) is a controlled intervention that optimizes negative margins without sacrificing tissue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>A comprehensive assessment of outcomes of MMS-treated facial MCC will help guide clinicians in surgical and medical management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods &amp; Materials<\/jats:title>\n                    <jats:p>Retrospective review identified facial MCC cases treated with MMS at a single institution from January 2005 to August 2020. Tumor characteristics and outcomes were recorded and descriptive and predictive analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>34 cases were reviewed with a mean followup of 34.4 months. The most common sites were the forehead, cheek-jaw region, and nasal ala. 2 (5.9%) patients had local recurrence by a mean of 4.3 months. No documented variables were significantly associated with local recurrence. 8 (23.5%) patients had progression to metastasis by a mean of 9.4 months. Younger age at biopsy and surgery, male sex, and intraoperative detection of in-transit disease were significantly associated with progression to metastasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In summary, the tissue-sparing approach of MMS may be beneficial for MCC in cosmetically and functionally sensitive facial locations as it preserves tissue without compromising outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/12034754221143080","type":"journal-article","created":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T00:53:45Z","timestamp":1670288025000},"page":"28-33","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Mohs Micrographic Surgery for Facial Merkel Cell Carcinoma"],"prefix":"10.1177","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2984-9433","authenticated-orcid":false,"given":"Brian J.","family":"Nguyen","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1100-4923","authenticated-orcid":false,"given":"Elana A.","family":"Meer","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sana A.","family":"Bautista","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana H.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy R.","family":"Etzkorn","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Pennsylvania, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan","family":"McGeehan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Pennsylvania, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesar A.","family":"Briceno","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,12,5]]},"reference":[{"key":"bibr1-12034754221143080","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.10.028"},{"key":"bibr2-12034754221143080","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(03)02108-X"},{"key":"bibr3-12034754221143080","doi-asserted-by":"publisher","DOI":"10.1126\/science.1152586"},{"key":"bibr4-12034754221143080","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-0702"},{"key":"bibr5-12034754221143080","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(97)70110-5"},{"key":"bibr6-12034754221143080","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-020-08587-3"},{"key":"bibr7-12034754221143080","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-016-5266-4"},{"key":"bibr8-12034754221143080","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2018.0055"},{"key":"bibr9-12034754221143080","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-018-6688-y"},{"key":"bibr10-12034754221143080","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.09.049"},{"key":"bibr11-12034754221143080","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2013.6077"},{"key":"bibr12-12034754221143080","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1997.tb00752.x"},{"key":"bibr13-12034754221143080","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.01.041"},{"key":"bibr14-12034754221143080","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.125083"},{"key":"bibr15-12034754221143080","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.16.3622"},{"key":"bibr16-12034754221143080","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-3401805"},{"key":"bibr17-12034754221143080","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10153"},{"issue":"3","key":"bibr18-12034754221143080","first-page":"333","volume":"33","author":"Thomas 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