{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T22:31:19Z","timestamp":1788993079331,"version":"build-2803163510"},"reference-count":56,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T00:00:00Z","timestamp":1676851200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Med Surg"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The lack of clinical guidelines for the treatment of primary psychodermatologic disorders (PPDs) hinders the delivery of optimal care to patients. The review aimed to identify, appraise, and summarize the currently available evidence about the safety and effectiveness of pharmacological management of PPDs through randomized controlled trials (RCTs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The Preferred Reporting Items for Systematic Review and Meta-Analyses (PRIMSA) statement and the Global Evidence Mapping Initiative guidance were followed. Medline, Embase, PsycInfo, Cochrane and Scopus were searched, and two reviewers independently completed article review, data extraction, and quality assessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 2618 unique studies, full texts of 83 were reviewed and 21 RCTs were included. Five PDDs were identified: trichotillomania ( n = 12), pathologic skin picking ( n = 5), nail biting ( n = 2), delusional parasitosis ( n = 1), and dermatitis from compulsive hand washing ( n = 1). Seven different classes of medications were investigated: SSRIs (i.e., fluoxetine, sertraline, and citalopram), tricyclic antidepressants (i.e., clomipramine and desipramine), antipsychotics (i.e., olanzapine and pimozide), anticonvulsant (i.e., lamotrigine), N-acetylcysteine, inositol, and milk thistle. RCT-derived evidence supports the use of antidepressants in trichotillomania (sertraline and clomipramine), pathologic skin picking (fluoxetine), pathologic nail biting and dermatitis from compulsive hand washing (clomipramine or desipramine); antipsychotics in trichotillomania (olanzapine) and delusional parasitosis (pimozide); N-acetyl cysteine in trichotillomania and skin picking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Few pharmacotherapies for primary psychodermatologic disorders are assessed through controlled trials in the literature. This review serves as a roadmap for researchers and clinicians to reach informed decisions with current evidence, and to build on it to establish guidelines in the future.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/12034754231155888","type":"journal-article","created":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T05:28:46Z","timestamp":1676870926000},"page":"140-149","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Pharmacological Interventions for Primary Psychodermatologic Disorders: An Evidence Mapping and Appraisal of Randomized Controlled Trials"],"prefix":"10.1177","volume":"27","author":[{"given":"Tarek","family":"Turk","sequence":"first","affiliation":[{"name":"Department of Psychiatry, University of Alberta, Edmonton, Canada"},{"name":"Department of Dermatology and Venereology, Syrian Arab Red Crescent Hospital, Ministry of Health, Damascus, Syria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4694-0116","authenticated-orcid":false,"given":"Chaocheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Skin Science, University of British Columbia, Vancouver, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Alberta, Edmonton, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Straube","sequence":"additional","affiliation":[{"name":"Division of Preventive Medicine, Department of Medicine, University of Alberta, Edmonton, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5698-6273","authenticated-orcid":false,"given":"Reidar","family":"Hagtvedt","sequence":"additional","affiliation":[{"name":"ABA, Alberta School of Business, University of Alberta, Edmonton, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liz","family":"Dennett","sequence":"additional","affiliation":[{"name":"Scott Health Sciences Library, University of Alberta, Edmonton, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Abba-Aji","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Alberta, Edmonton, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlene","family":"Dytoc","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine, University of Alberta, Edmonton, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,2,20]]},"reference":[{"key":"bibr1-12034754231155888","doi-asserted-by":"publisher","DOI":"10.4088\/PCC.v09n0306"},{"key":"bibr2-12034754231155888","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2009.04.003"},{"key":"bibr3-12034754231155888","doi-asserted-by":"publisher","DOI":"10.1007\/s00787-017-1074-z"},{"key":"bibr4-12034754231155888","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2020.0394"},{"issue":"2","key":"bibr5-12034754231155888","volume":"17","author":"Ocek T.","year":"2015","journal-title":"Prim Care Companion CNS Disord"},{"key":"bibr6-12034754231155888","doi-asserted-by":"publisher","DOI":"10.1111\/dth.14024"},{"key":"bibr7-12034754231155888","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13286"},{"key":"bibr8-12034754231155888","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2016.04.001"},{"key":"bibr9-12034754231155888","doi-asserted-by":"publisher","DOI":"10.1002\/da.23028"},{"key":"bibr10-12034754231155888","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-019-00324-3"},{"key":"bibr11-12034754231155888","doi-asserted-by":"publisher","DOI":"10.5070\/D3195018169"},{"key":"bibr12-12034754231155888","doi-asserted-by":"publisher","DOI":"10.1111\/ced.14641"},{"key":"bibr13-12034754231155888","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-11-92"},{"key":"bibr14-12034754231155888","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003583"},{"issue":"2","key":"bibr15-12034754231155888","first-page":"130","volume":"94","author":"Glanville JM.","year":"2006","journal-title":"J Med Libr Assoc"},{"key":"bibr16-12034754231155888","unstructured":"Oxford Center for Evidence Based Medicine. Accessed November 10, 2022. https:\/\/www.cebm.net"},{"key":"bibr17-12034754231155888","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.148.11.1566"},{"key":"bibr18-12034754231155888","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.152.8.1192"},{"key":"bibr19-12034754231155888","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v67n0711"},{"key":"bibr20-12034754231155888","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2012.12.020"},{"key":"bibr21-12034754231155888","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2009.60"},{"key":"bibr22-12034754231155888","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198908243210803"},{"key":"bibr23-12034754231155888","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v61n0111"},{"key":"bibr24-12034754231155888","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000000037"},{"key":"bibr25-12034754231155888","doi-asserted-by":"publisher","DOI":"10.1097\/YIC.0000000000000156"},{"key":"bibr26-12034754231155888","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000001005"},{"key":"bibr27-12034754231155888","doi-asserted-by":"publisher","DOI":"10.1176\/appi.psy.42.4.314"},{"key":"bibr28-12034754231155888","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v58n0802"},{"key":"bibr29-12034754231155888","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e3181e617a1"},{"key":"bibr30-12034754231155888","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2016.0060"},{"key":"bibr31-12034754231155888","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1991.01810330045007"},{"key":"bibr32-12034754231155888","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(90)90024-Y"},{"key":"bibr33-12034754231155888","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.09m05114gre"},{"key":"bibr34-12034754231155888","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.5.517"},{"issue":"1","key":"bibr35-12034754231155888","doi-asserted-by":"crossref","first-page":"55","DOI":"10.2340\/00015555625558","volume":"62","author":"Hamann K.","year":"1982","journal-title":"Acta Derm Venereol"},{"issue":"5","key":"bibr36-12034754231155888","first-page":"367","volume":"1","author":"Arbabi MFV.","year":"2008","journal-title":"Acta Med Iran"},{"key":"bibr37-12034754231155888","doi-asserted-by":"publisher","DOI":"10.2174\/1871523011312030003"},{"key":"bibr38-12034754231155888","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.21668"},{"key":"bibr39-12034754231155888","doi-asserted-by":"publisher","DOI":"10.1186\/1471-244X-5-2"},{"key":"bibr40-12034754231155888","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2006.07.016"},{"key":"bibr41-12034754231155888","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30897"},{"key":"bibr42-12034754231155888","doi-asserted-by":"publisher","DOI":"10.1007\/s12041-011-0094-6"},{"key":"bibr43-12034754231155888","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001898"},{"key":"bibr44-12034754231155888","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145711001829"},{"key":"bibr45-12034754231155888","doi-asserted-by":"publisher","DOI":"10.1080\/j.1440-1614.2005.01591.x"},{"key":"bibr46-12034754231155888","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18508"},{"key":"bibr47-12034754231155888","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2018.20.3\/mdavidson"},{"key":"bibr48-12034754231155888","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-021-01789-0"},{"key":"bibr49-12034754231155888","doi-asserted-by":"publisher","DOI":"10.1038\/508S14a"},{"key":"bibr50-12034754231155888","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.08.025"},{"key":"bibr51-12034754231155888","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2018.02.015"},{"key":"bibr52-12034754231155888","doi-asserted-by":"publisher","DOI":"10.1002\/ski2.151"},{"key":"bibr53-12034754231155888","doi-asserted-by":"publisher","DOI":"10.1111\/dth.15824"},{"key":"bibr54-12034754231155888","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2014.972936"},{"key":"bibr55-12034754231155888","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000000462"},{"key":"bibr56-12034754231155888","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2020.1795061"}],"container-title":["Journal of Cutaneous Medicine and Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/12034754231155888","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/12034754231155888","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/12034754231155888","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:49:42Z","timestamp":1777391382000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1177\/12034754231155888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,20]]},"references-count":56,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1177\/12034754231155888"],"URL":"https:\/\/doi.org\/10.1177\/12034754231155888","relation":{},"ISSN":["1203-4754","1615-7109"],"issn-type":[{"value":"1203-4754","type":"print"},{"value":"1615-7109","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,20]]}}}