{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T18:33:47Z","timestamp":1792694027607,"version":"4.5.0"},"reference-count":18,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T00:00:00Z","timestamp":1677110400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Med Surg"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Lichen Planus (LP) is a dermatological disorder characterized by violaceous papules that affect the cutaneous region, nails, scalp, and mucous membranes. Current molecular and clinical studies point to the Janus Kinase-signal transducer and activator of transcription (JAK-STAT) pathway as a potential effector of LP pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This systematic review summarizes the current reported literature outcomes for patients receiving JAK inhibitors to treat LP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>MEDLINE and Embase were searched on 16 October, 2022, and 15 original articles were included, with 56 LP patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>(mean age: 54.5 years, range: 26-81 years, male: 26.8%). The treatment outcomes were included for the following JAK inhibitors: tofacitinib ( n = 30), baricitinib ( n = 16), ruxolitinib ( n = 12), and upadacitinib ( n = 2). Patient outcomes were classified into complete resolution, partial resolution, and no resolution. Patients achieving complete resolution represented 25% ( n = 4\/16) in the baricitinib group, 10% ( n = 3\/30) in the tofacitinib group, 16.7% ( n = 2\/12) in the ruxolitinib group, and 100% (2\/2) in the upadacitinib group. Partial resolution patients represented 31.3% ( n = 5\/16) of baricitinib patients, 60% ( n = 18\/30) of tofacitinib patients, and 83% ( n = 10\/12) of ruxolitinib patients. 43.8% ( n = 7\/16) of baricitinib patients and 10% ( n = 9\/30) of tofacitinib patients had no resolution of lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This review also highlights the significance of utilizing a uniform outcome measure for LP, as it aids in reporting more generalizable results, reduces reporting bias, and ultimately lead to improved clinical outcomes for LP patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/12034754231156100","type":"journal-article","created":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T09:11:31Z","timestamp":1677143491000},"page":"271-276","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":57,"title":["The Use of Janus Kinase Inhibitors for Lichen Planus: An Evidence-Based Review"],"prefix":"10.1177","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9137-5876","authenticated-orcid":false,"given":"Abrahim","family":"Abduelmula","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Western Ontario, London, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Bagit","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3514-9513","authenticated-orcid":false,"given":"Asfandyar","family":"Mufti","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine, University of Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3629-9131","authenticated-orcid":false,"given":"Katie C.Y.","family":"Yeung","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Queen\u2019s University, Kingston, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jensen","family":"Yeung","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine, University of Toronto, Ontario, Canada"},{"name":"Women\u2019s College Research Institute, Women\u2019s College Hospital, Toronto, Ontario, Canada"},{"name":"Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada"},{"name":"Probity Medical Research, Waterloo, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,2,23]]},"reference":[{"key":"bibr1-12034754231156100","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(91)70241-S"},{"key":"bibr2-12034754231156100","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.04.027"},{"key":"bibr3-12034754231156100","doi-asserted-by":"publisher","DOI":"10.1155\/2007\/19854"},{"issue":"5","key":"bibr4-12034754231156100","first-page":"1161","volume":"19","author":"Nosratzehi T","year":"2018","journal-title":"Asian Pac J Cancer Prev"},{"issue":"3","key":"bibr5-12034754231156100","first-page":"5","volume":"23","author":"Cinats A.","year":"2018","journal-title":"Skin Therapy Lett"},{"key":"bibr6-12034754231156100","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aav7561"},{"key":"bibr7-12034754231156100","volume-title":"Oxford centre for evidence-based medicine: levels of evidence. 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