{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T01:49:57Z","timestamp":1777513797945,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T00:00:00Z","timestamp":1691539200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100019211","name":"AbbVie Corporation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100019211","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Med Surg"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Psoriasis is a chronic inflammatory skin disease with a strong genetic predisposition and autoimmune component that is often treated with immunomodulators such as biologic therapy. Guselkumab is a biologic treatment option that selectively targets the p19 subunit of interleukin (IL)\u221223; risankizumab is a more recently developed monoclonal antibody of the same class that targets IL-23p19. There is limited research around effective treatment response with intra class switching within IL-23-targeted therapies for the treatment of moderate-to-severe plaque psoriasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The purpose is to assess patient response to risankizumab after guselkumab failure for the treatment of plaque psoriasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective chart review was conducted for 13 patients meeting inclusion criteria. Physical examination findings were converted to a 5-point static physicians\u2019 global assessment (sPGA) score. Baseline, 4-month, and 12-month sPGA scores were assigned from visits immediately prior to and during their course of risankizumab treatment. sPGA scores were analyzed to compare changes between baseline and 4 months and 12 months of therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients treated with risankizumab had lower sPGA scores after both 4 and 12 months compared to their baseline sPGA score. 46% of patients met the primary outcome of an sPGA score of 0 or 1 at 4 months of risankizumab, increasing to 90% of patients at 12 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings reflect an improvement in sPGA scores when patients are treated with risankizumab following guselkumab failure. This highlights the benefit of in-class switch to risankizumab when patients with moderate-to-severe plaque psoriasis have failed multiple treatments including guselkumab.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/12034754231191458","type":"journal-article","created":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T02:23:50Z","timestamp":1691634230000},"page":"476-480","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["The Effectiveness of Risankizumab Following Guselkumab Failure in Moderate-to-Severe Psoriasis Patients: A Retrospective Study"],"prefix":"10.1177","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5158-9319","authenticated-orcid":false,"given":"Camille","family":"Hamm","sequence":"first","affiliation":[{"name":"The Ottawa Hospital Division of Dermatology, Ottawa, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nusha","family":"Ramsoondar","sequence":"additional","affiliation":[{"name":"Northern Ontario School of Medicine University, Undergraduate Medical Education, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2802-0591","authenticated-orcid":false,"given":"Michaela","family":"McGillis","sequence":"additional","affiliation":[{"name":"Northern Ontario School of Medicine University, Undergraduate Medical Education, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0989-3055","authenticated-orcid":false,"given":"Miranda","family":"Waugh","sequence":"additional","affiliation":[{"name":"The Ottawa Hospital Division of Dermatology, Ottawa, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8926-0113","authenticated-orcid":false,"given":"Melinda","family":"Gooderham","sequence":"additional","affiliation":[{"name":"Department of Medicine, Queen\u2019s University, Kingston, Canada"},{"name":"SKiN Centre for Dermatology, Peterborough, United Kingdom"},{"name":"Probity Medical Research, Peterborough, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7840-7781","authenticated-orcid":false,"given":"Lyne L.","family":"Giroux","sequence":"additional","affiliation":[{"name":"Northern Ontario School of Medicine University, Undergraduate Medical Education, Canada"},{"name":"Sudbury Skin Clinique, Sudbury, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,8,9]]},"reference":[{"key":"bibr1-12034754231191458","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2018.09.002"},{"key":"bibr2-12034754231191458","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2020.0723"},{"key":"bibr3-12034754231191458","doi-asserted-by":"publisher","DOI":"10.2147\/PTT.S294189"},{"key":"bibr4-12034754231191458","doi-asserted-by":"publisher","DOI":"10.51731\/cjht.2021.197"},{"key":"bibr5-12034754231191458","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-017-0800-7"},{"key":"bibr6-12034754231191458","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-019-01136-7"},{"key":"bibr7-12034754231191458","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.19575"},{"key":"bibr8-12034754231191458","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13132"},{"key":"bibr9-12034754231191458","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.04.025"},{"key":"bibr10-12034754231191458","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21207488"},{"key":"bibr11-12034754231191458","doi-asserted-by":"publisher","DOI":"10.1080\/19420862.2021.1964420"},{"key":"bibr12-12034754231191458","doi-asserted-by":"publisher","DOI":"10.1111\/dth.14374"},{"key":"bibr13-12034754231191458","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31713-6"},{"key":"bibr14-12034754231191458","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30952-3"},{"issue":"5","key":"bibr15-12034754231191458","volume":"177","author":"Blauvelt 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