{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:33:45Z","timestamp":1791977625343,"version":"4.4.0"},"reference-count":16,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T00:00:00Z","timestamp":1691712000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Med Surg"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acne vulgaris is a worldwide dermatological condition that has a complex pathophysiology in which androgens play an important role. Flutamide is a first-generation non-steroidal antiandrogen that can be used for acne treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the potential therapeutic efficacy and safety of topical flutamide in the treatment of acne vulgaris.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A andomized controlled study included two equal groups, each had 27 patients, with a total of 54 patients with mild to moderate acne vulgaris having inflammatory (papules and pustules) and non-inflammatory (comedones) lesions. For eight weeks, Group (A) received 1% Flutamide topical gel on the face twice daily, whereas Group (B) served as the control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>After 8 weeks of topical Flutamide 1% gel application twice daily, there was a significant reduction in papules count, and a highly significant reduction in pustules number from baseline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Limitations<\/jats:title>\n                    <jats:p>We recommend that topical Flutamide 1% gel be tried on a larger number of patients with acne vulgaris, for longer therapeutic duration and follow up periods after treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients with acne vulgaris may find topical Flutamide 1% gel to be a viable, efficient, and safe solution with few adverse effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/12034754231191475","type":"journal-article","created":{"date-parts":[[2023,8,12]],"date-time":"2023-08-12T02:16:01Z","timestamp":1691806561000},"page":"472-475","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy and Safety of Topical Flutamide 1% Gel as an Adjunctive Therapy in the Treatment of Patients With Acne Vulgaris"],"prefix":"10.1177","volume":"27","author":[{"given":"Amany","family":"Nassar","sequence":"first","affiliation":[{"name":"Dermatology, Venereology and Andrology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayman El","family":"Sayed","sequence":"additional","affiliation":[{"name":"Dermatology, Venereology and Andrology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afnan","family":"Samy","sequence":"additional","affiliation":[{"name":"Dermatology, Venereology and Andrology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5648-6842","authenticated-orcid":false,"given":"Reham","family":"Essam","sequence":"additional","affiliation":[{"name":"Dermatology, Venereology and Andrology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,8,11]]},"reference":[{"key":"bibr1-12034754231191475","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.15415"},{"key":"bibr2-12034754231191475","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2016.10.004"},{"key":"bibr3-12034754231191475","doi-asserted-by":"publisher","DOI":"10.4103\/2229-5178.144506"},{"key":"bibr4-12034754231191475","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2021.1918100"},{"key":"bibr5-12034754231191475","doi-asserted-by":"publisher","DOI":"10.1016\/j.eucr.2020.101370"},{"key":"bibr6-12034754231191475","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1997.00099.x"},{"key":"bibr7-12034754231191475","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.15210"},{"key":"bibr8-12034754231191475","doi-asserted-by":"publisher","DOI":"10.1097\/01.EWX.0000546169.90015.65"},{"key":"bibr9-12034754231191475","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-019-01908-x"},{"key":"bibr10-12034754231191475","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2002.01594.x"},{"key":"bibr11-12034754231191475","doi-asserted-by":"publisher","DOI":"10.1016\/0303-7207(86)90132-2"},{"key":"bibr12-12034754231191475","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1993.tb01768.x"},{"key":"bibr13-12034754231191475","first-page":"4219","volume":"9","author":"Adalatkhah 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