{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T07:05:57Z","timestamp":1784271957016,"version":"3.55.0"},"reference-count":15,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Med Surg"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Skin diseases have been shown to worsen psychological distress, which, in turn, may be detrimental to treatment outcomes. Both the impact of psychological distress on response to treatment in mycosis fungoides (MF) and the effect of treatments on psychological well-being are unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To evaluate (1) the association between pretreatment psychological morbidity and treatment outcome in early-stage MF and (2) the impact of response to treatment on psychological well-being.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This was a prospective cohort study of patients with early-stage MF who started a new stage-directed treatment for their disease. The response was determined using the modified severity-weighted assessment tool, and psychological distress was assessed using the 12-item General Health Questionnaire (GHQ-12) and Penn State Worry Questionnaire (PSWQ). Participants were followed for 1 year.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      In all, 24 consecutive patients were recruited. Objective response rate was 71% (17\/24), consistent with existing literature. Prior to treatment, 9 patients (38%) had clinically significant psychological distress on the GHQ-12, while 8 (33%) demonstrated high-level worry on the PSWQ. Of these patients, 6 had pathologic scores on both instruments. Patients with significantly less baseline anxiety\/depression on the GHQ-12 responded better to treatment than patients with higher levels (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .004). In addition, responders\u2019 mean GHQ-12 scores decreased by 39% and their PSWQ scores by 17%, whereas nonresponders\u2019 GHQ-12 scores increased by 93% (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .042) and their PSWQ scores by 11% (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .019).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>These findings suggest that (1) baseline psychological distress is associated with worse outcomes in patients with early-stage MF and that (2) effective treatment improves psychological morbidity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/12034754231220913","type":"journal-article","created":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T00:46:10Z","timestamp":1705452370000},"page":"29-32","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Psychological Distress and Treatment Outcome in Patients With Early-Stage Mycosis Fungoides"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4622-2931","authenticated-orcid":false,"given":"Meagan-Helen","family":"Henderson Berg","sequence":"first","affiliation":[{"name":"Division of Dermatology, McGill University, Montr\u00e9al, QC, Canada"},{"name":"Lady Davis Institute, Jewish General Hospital, McGill University, Montr\u00e9al, QC, Canada"},{"name":"McGill Multidisciplinary Cutaneous Lymphoma Clinic, Montr\u00e9al, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gizelle","family":"Popradi","sequence":"additional","affiliation":[{"name":"McGill Multidisciplinary Cutaneous Lymphoma Clinic, Montr\u00e9al, QC, Canada"},{"name":"Division of Hematology, McGill University, Montr\u00e9al, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8747-648X","authenticated-orcid":false,"given":"David","family":"Roberge","sequence":"additional","affiliation":[{"name":"McGill Multidisciplinary Cutaneous Lymphoma Clinic, Montr\u00e9al, QC, Canada"},{"name":"Division of Radiation Oncology, Centre Hospitalier de l\u2019Universite de Montreal, Montr\u00e9al, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Petrogiannis-Haliotis","sequence":"additional","affiliation":[{"name":"McGill Multidisciplinary Cutaneous Lymphoma Clinic, Montr\u00e9al, QC, Canada"},{"name":"Department of Pathology, Jewish General Hospital, McGill University, Montr\u00e9al, QC, Canada"},{"name":"Division of Hematology, Department of Medicine, Sir Mortimer B. Davis Jewish General Hospital, Montr\u00e9al, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Pehr","sequence":"additional","affiliation":[{"name":"Division of Dermatology, McGill University, Montr\u00e9al, QC, Canada"},{"name":"Lady Davis Institute, Jewish General Hospital, McGill University, Montr\u00e9al, QC, Canada"},{"name":"McGill Multidisciplinary Cutaneous Lymphoma Clinic, Montr\u00e9al, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,1,16]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-11-881268"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18089"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13922"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22252"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06565.x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.139.6.752"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.00330"},{"key":"e_1_3_2_9_2","volume-title":"The Detection of Psychiatric Illness by Questionnaire","author":"Goldberg D","year":"1972","unstructured":"Goldberg D. 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NFER-Nelson; 1988."},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.32.0630"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.19252"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.36849\/JDD.5608"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08992.x"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(20)30308-4"}],"container-title":["Journal of Cutaneous Medicine and Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/12034754231220913","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/12034754231220913","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/12034754231220913","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T06:46:07Z","timestamp":1784270767000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/12034754231220913"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1177\/12034754231220913"],"URL":"https:\/\/doi.org\/10.1177\/12034754231220913","relation":{},"ISSN":["1203-4754","1615-7109"],"issn-type":[{"value":"1203-4754","type":"print"},{"value":"1615-7109","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]}}}