{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T01:52:28Z","timestamp":1777513948702,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T00:00:00Z","timestamp":1707091200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Med Surg"],"published-print":{"date-parts":[[2024,5]]},"abstract":"\n Background:<\/jats:title>\n \n Common cutaneous non-genital viral warts are a common skin infection with significant morbidity in the pediatric population. Although various therapeutics are available, many of them necessitate recurrent patient visits and may be associated with significant irritation and pain. Verrulyse Methionine\n \u00ae<\/jats:sup>\n (VM), a nutritional supplement, was previously suggested as a non-invasive treatment option for the disease.\n <\/jats:p>\n <\/jats:sec>\n \n Objective:<\/jats:title>\n To assess the response to oral VM supplement as a monotherapy in a cohort of children and adolescents with multiple, non-genital viral warts after failing previous treatments.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n We reviewed medical records of pediatric patients (<18\u2009y\/o) with viral warts treated with VM between 2010 and 2021.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n Among 25 patients with multiple verrucae vulgaris lesions who failed previous treatments, 14 (56%) had complete or almost-complete response to VM within 4\u2009months, after an average of 18\u2009months of active disease prior to VM treatment initiation. None of the 4 patients with verruca plana had response to VM treatment. Favourable cosmetic results were found in responders, and no adverse events were recorded.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Response rates in our cohort are comparable to those reported in the literature for destructive local therapeutics for viral warts. Thus, our data suggest that VM may be considered for children with multiple verrucae vulgaris, providing a painless and non-invasive therapeutic option for this common disease.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/12034754241230691","type":"journal-article","created":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T07:52:25Z","timestamp":1707119545000},"page":"248-252","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Verrulyse Methionine\n \u00ae<\/sup>\n as Monotherapy in Children and Adolescents With Common Warts"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8117-3656","authenticated-orcid":false,"given":"Rivka","family":"Friedland","sequence":"first","affiliation":[{"name":"Pediatric Dermatology Unit, Schneider Children\u2019s Medical Center of Israel, Petah Tikva, Israel"},{"name":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yael","family":"Renert-Yuval","sequence":"additional","affiliation":[{"name":"Pediatric Dermatology Unit, Schneider Children\u2019s Medical Center of Israel, Petah Tikva, Israel"},{"name":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Efrat","family":"Solomon-Cohen","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"},{"name":"Division of Dermatology, Rabin Medical Center, Petah Tikva, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiran","family":"Reiss-Huss","sequence":"additional","affiliation":[{"name":"Pediatric Dermatology Unit, Schneider Children\u2019s Medical Center of Israel, Petah Tikva, Israel"},{"name":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Ben Amitai","sequence":"additional","affiliation":[{"name":"Pediatric Dermatology Unit, Schneider Children\u2019s Medical Center of Israel, Petah Tikva, Israel"},{"name":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,2,5]]},"reference":[{"key":"bibr1-12034754241230691","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2016.04.010"},{"key":"bibr2-12034754241230691","doi-asserted-by":"publisher","DOI":"10.1111\/dth.14034"},{"key":"bibr3-12034754241230691","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1963.01590150022004"},{"key":"bibr4-12034754241230691","doi-asserted-by":"publisher","DOI":"10.1097\/01.mop.0000128403.78839.3c"},{"key":"bibr5-12034754241230691","doi-asserted-by":"publisher","DOI":"10.24953\/turkjped.2020.06.015"},{"key":"bibr6-12034754241230691","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph192416400"},{"key":"bibr7-12034754241230691","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2003.20605.x"},{"issue":"5","key":"bibr8-12034754241230691","first-page":"421","volume":"112","author":"Kacar SD","year":"2014","journal-title":"Arch Argent 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