{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T01:53:35Z","timestamp":1777514015406,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T00:00:00Z","timestamp":1716163200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Med Surg"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Seeding of skin cancer cells following diagnostic or therapeutic surgical procedures can occur and might cause local recurrences. As current preferred therapy for skin malignancy is surgical excision, seeding of tumour cells by manipulating malignant tissue or suturing can be another factor leading to recurrences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To evaluate whether genetic material and malignant cells adhere to standard suture materials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This prospective study included patients who underwent excision of skin lesions. Monofilament and braided sutures were examined. Sutures were passed through the observed tumour or healthy skin margins and were examined for DNA material and cells by cytological analysis, cell culture and characterization, and DNA analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Twenty-two patients and 148 sutures were included. DNA quantification showed DNA material on all sutures, with no significant difference between braided and monofilament sutures. Cytological analysis showed that all slides prepared from cell blocks contained normal squamous and atypical cells. Cell culture and characterization showed viable cells adhering to the sutures under direct light microscopy. Cell cultures showed rapid proliferation of epithelial cells from squamous cell carcinoma specimens.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Suture materials carry DNA material and cells, including malignant cells of cutaneous origin and may seed them at distant sites.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/12034754241253189","type":"journal-article","created":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T07:37:04Z","timestamp":1716190624000},"page":"360-364","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Transmission of Genetic Material and Malignant Cells of Cutaneous Origin via Surgical Sutures"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3705-5454","authenticated-orcid":false,"given":"Ariel","family":"Berl","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery, Meir Medical Center, Kfar Saba, Israel, Affiliated with the Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7942-6394","authenticated-orcid":false,"given":"Ofir","family":"Shir-az","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Meir Medical Center, Kfar Saba, Israel, Affiliated with the Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shelly","family":"Tartakover-Matalon","sequence":"additional","affiliation":[{"name":"The Autoimmune Research Laboratory, Meir Medical Center, Kfar Saba, Israel, Affiliated with the Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir","family":"Kravtsov","sequence":"additional","affiliation":[{"name":"Department of Pathology, Meir Medical Center, Kfar Saba, Israel, Affiliated with the Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Golberg","sequence":"additional","affiliation":[{"name":"Porter School of Environment and Earth Sciences, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1818-7876","authenticated-orcid":false,"given":"Mrinal","family":"Kashyap","sequence":"additional","affiliation":[{"name":"Porter School of Environment and Earth Sciences, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avshalom","family":"Shalom","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Meir Medical Center, Kfar Saba, Israel, Affiliated with the Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,5,20]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.32113\/wcrj_20194_1265"},{"key":"e_1_3_2_3_2","unstructured":"American Cancer Society. Cancer facts and figures 2023. Updated 2023. Accessed November 5 2023. https:\/\/www.cancer.org\/research\/cancer-facts-statistics\/all-cancer-facts-figures\/2023-cancer-facts-figures.html"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930530313"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.4103\/2231-0762.129446"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(195909\/10)12:5<1029::aid-cncr2820120524>3.0.co;2-q"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.930715"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.13936"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000505392"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10585-018-9896-8"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2009.06.013"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1097-0347(199603\/04)18:2<107::aid-hed1>3.0.co;2-5"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30370."},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-023-06553-0"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800760405"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930080307"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2009.01340.x"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1096-9071(199709)53:1<13::aid-jmv3>3.0.co;2-t"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.30250"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsurg.2010.09.015"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-16-1536"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800720621"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02047382"}],"container-title":["Journal of Cutaneous Medicine and Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/12034754241253189","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/12034754241253189","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/12034754241253189","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:50:43Z","timestamp":1777391443000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/12034754241253189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,20]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1177\/12034754241253189"],"URL":"https:\/\/doi.org\/10.1177\/12034754241253189","relation":{},"ISSN":["1203-4754","1615-7109"],"issn-type":[{"value":"1203-4754","type":"print"},{"value":"1615-7109","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,20]]}}}