{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T03:56:54Z","timestamp":1788494214788,"version":"build-2803163510"},"reference-count":38,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T00:00:00Z","timestamp":1717718400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Med Surg"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:p>There has been a call to action to enhance representation of non-white individuals in dermatology clinical trials. Investigations in differential response to treatment across populations are limited, particularly in conditions of commonality, impact, distinct presentation, and diagnosis in non-white participants, such as atopic dermatitis and psoriasis. This systematic review summarized and identified if biologic treatment outcomes in moderate-to-severe atopic dermatitis and psoriasis varied in skin of colour (SOC) participants in phase 3 trials. MEDLINE, COCHRANE, and EMBASE databases were used to conduct the search following PROSPERO registration. Following screening of 3209 articles, 11 studies were collected with 1781 SOC participants with a mean age of 40.99\u2009\u00b1\u20096.3\u2009years (range: 30.6-51.6\u2009years). Male participants accounted for 76.9% (n\u2009=\u20091370\/1781) of the sample, and Chinese, Japanese, Taiwanese, and Korean participants accounted for 64.3%, 24.2%, 4.5%, and 3.4% of participants, respectively. Participants with atopic dermatitis were treated with dupilumab (n\u2009=\u2009216\/388) and participants with psoriasis were treated with adalimumab (n\u2009=\u2009313\/1393), bimekizumab (n\u2009=\u200962\/1393), ixekizumab (n\u2009=\u200913\/1393), secukinumab (n\u2009=\u2009117\/1393), and ustekinumab (n\u2009=\u2009289\/1393). No significant SOC population-based outcomes were found across treatment groups. However, differences in baseline characteristics or comorbidities were found, suggesting race or ethnic background should be considered when treatment is prescribed in psoriasis or atopic dermatitis. Although no significant SOC participant differential response to treatment were found, large-scale randomized controlled trials investigating comparable treatment outcomes and stratifying results by SOC population in atopic dermatitis and psoriasis are warranted to confirm these findings.<\/jats:p>","DOI":"10.1177\/12034754241260023","type":"journal-article","created":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T07:49:56Z","timestamp":1717746596000},"page":"468-472","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Response to Biologic Therapy in Skin of Colour Participants With Moderate-to-Severe Psoriasis and Atopic Dermatitis: A Systematic Review"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7432-3456","authenticated-orcid":false,"given":"Hibo","family":"Rijal","sequence":"first","affiliation":[{"name":"Queen\u2019s University School of Medicine, Kingston, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9654-1510","authenticated-orcid":false,"given":"Na\u00efla","family":"Bouadi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universit\u00e9 Laval, Qu\u00e9bec City, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abrahim","family":"Abduelmula","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2298-8374","authenticated-orcid":false,"given":"Khalad","family":"Maliyar","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrienn N.","family":"Bourkas","sequence":"additional","affiliation":[{"name":"Queen\u2019s University School of Medicine, Kingston, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6844-2724","authenticated-orcid":false,"given":"Jorge-Ryan","family":"Georgakopoulos","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jensen","family":"Yeung","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine, University of Toronto, Toronto, ON, Canada"},{"name":"Women\u2019s College Research Institute, Women\u2019s College Hospital, Toronto, ON, Canada"},{"name":"Sunnybrook Health Sciences Centre, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,6,7]]},"reference":[{"key":"bibr1-12034754241260023","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0244620"},{"key":"bibr2-12034754241260023","unstructured":"US Department of Health and Human Services. 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