{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T01:53:53Z","timestamp":1777514033173,"version":"3.51.4"},"reference-count":9,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T00:00:00Z","timestamp":1721952000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Med Surg"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:p>Alopecia areata totalis and universalis are disabling conditions and therapeutically challenging as they are refractory to conventional options. Tofacitinib is a Janus-kinase (JAK) inhibitor utilized to treat alopecia areata (AA) as an off-label drug. In India, FDA-approved JAK inhibitors such as baricitinib and ritlecitinib are not available. There are only a few case reports on tofacitinib in AA in the Indian population. We present the data of 9 pediatric cases of clinically and histologically proven alopecia areata totalis (AT) and alopecia universalis (AU), for whom oral tofacitinib was given after baseline investigations. The following parameters were analysed: Photographic image and severity of alopecia tool (SALT) score at baseline, 3\u2009months and 6\u2009months, and Children Dermatology Life Quality Index (cDLQI) at baseline and 6\u2009months. The mean\u2009\u00b1\u2009standard deviation ( M\u2009\u00b1\u2009SD) of the SALT score and cDLQI( M\u2009\u00b1\u2009SD) at baseline were 95\u2009\u00b1\u20095 and 17\u2009\u00b1\u20092. At weeks 4 and weeks 12, the SALT ( M\u2009\u00b1\u2009SD) score was 92.7\u2009\u00b1\u20096.1 and 34.35\u2009\u00b1\u200911.16, respectively. At weeks 24, the SALT ( M\u2009\u00b1\u2009SD) score and cDLQI ( M\u2009\u00b1\u2009SD) were 3.33\u2009\u00b1\u20095 and 6\u2009\u00b1\u20092. The final reduction in SALT score from the baseline was 100% in 6\/9 cases (66.67%), 75% to 99% in 3\/9 (22.23%), and 50 to 75% in 1\/9 (11.12%). We also observed minimal adverse effects (one child developed herpes zoster) with tofacitinib. Our study demonstrates that oral tofacitinib represents a viable modality in managing difficult-to-treat pediatric AA, such as AT and AU, with a good safety profile.<\/jats:p>","DOI":"10.1177\/12034754241266128","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T06:37:33Z","timestamp":1721975853000},"page":"497-502","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Tofacitinib in Pediatric Alopecia Areata Totalis and Alopecia Universalis: A Retrospective Analysis From India"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3378-5492","authenticated-orcid":false,"given":"Shreya K.","family":"Gowda","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology, All India Institute of Medical Sciences, Bhubaneswar, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1985-6744","authenticated-orcid":false,"given":"Akash","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, All India Institute of Medical Sciences, Bhubaneswar, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0495-6571","authenticated-orcid":false,"given":"Vishal","family":"Thakur","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, All India Institute of Medical Sciences, Bhubaneswar, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biswanath","family":"Behera","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, All India Institute of Medical Sciences, Bhubaneswar, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonika","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, All India Institute of Medical Sciences, Bhubaneswar, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madhusmita","family":"Sethy","sequence":"additional","affiliation":[{"name":"Department of Pathology and Lab Medicine, All India Institute of Medical Sciences, Bhubaneswar, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavithra","family":"Ayyanar","sequence":"additional","affiliation":[{"name":"Department of Pathology and Lab Medicine, All India Institute of Medical Sciences, Bhubaneswar, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,7,26]]},"reference":[{"key":"bibr1-12034754241266128","doi-asserted-by":"publisher","DOI":"10.5021\/ad.21.202"},{"key":"bibr2-12034754241266128","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2022.6687"},{"key":"bibr3-12034754241266128","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.09.007"},{"key":"bibr4-12034754241266128","doi-asserted-by":"publisher","DOI":"10.1111\/pde.14422"},{"key":"bibr5-12034754241266128","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2022.0351"},{"key":"bibr6-12034754241266128","doi-asserted-by":"publisher","DOI":"10.25259\/IJDVL_975_19"},{"key":"bibr7-12034754241266128","doi-asserted-by":"publisher","DOI":"10.2340\/actadv.v103.13418"},{"key":"bibr8-12034754241266128","doi-asserted-by":"publisher","DOI":"10.4103\/ijt.ijt_15_22"},{"key":"bibr9-12034754241266128","first-page":"516","volume":"1","author":"Swetha Sri S","year":"2022","journal-title":"Specialusis Ugdymas"}],"container-title":["Journal of Cutaneous Medicine and Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/12034754241266128","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/12034754241266128","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/12034754241266128","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:50:47Z","timestamp":1777391447000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/12034754241266128"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,26]]},"references-count":9,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1177\/12034754241266128"],"URL":"https:\/\/doi.org\/10.1177\/12034754241266128","relation":{},"ISSN":["1203-4754","1615-7109"],"issn-type":[{"value":"1203-4754","type":"print"},{"value":"1615-7109","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,26]]}}}