{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:56:26Z","timestamp":1793040986856,"version":"4.5.0"},"reference-count":21,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,12,14]],"date-time":"2024-12-14T00:00:00Z","timestamp":1734134400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,12,14]],"date-time":"2024-12-14T00:00:00Z","timestamp":1734134400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100013671","name":"Sun Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013671","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Med Surg"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Tildrakizumab is an interleukin-23 inhibitor approved in Canada in 2021 for the treatment of adults with moderate-to-severe plaque psoriasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To evaluate real-world effectiveness of tildrakizumab for the treatment of moderate-to-severe plaque psoriasis in Canada.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A multicenter, retrospective study was conducted in Canada in adults with moderate-to-severe plaque psoriasis for \u22651 year treated with tildrakizumab for \u226512 weeks. Effectiveness was evaluated from proportions of patients achieving \u226575%\/\u226590%\/100% improvement from baseline in Psoriasis Area and Severity Index (PASI 75\/90\/100 response) and Physician Global Assessment (PGA) 0 or 1 at weeks 16 (\u00b14), 24 (\u00b18), and 48 (\u00b112). Subgroup analyses were performed based on prior biologic use and special site involvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The study included 75 patients (mean age, 50.5 years; 52.0% female; 82.7% bio-na\u00efve; 73.3% with special site involvement). Absolute mean (standard deviation) PASI score improved from 16.1 (6.7) at baseline to 1.3 (1.7) at the week 48 (91.7% improvement), 95.7%\/69.6%\/34.8% of patients achieved PASI 75\/90\/100 response, and 93.0% achieved PGA 0\/1 at the week 48. In subgroup analyses, 94.7%\/71.1%\/34.2% of bio-na\u00efve patients, 100.0%\/62.5%\/37.5% of bio-experienced patients, 100.0%\/71.4%\/28.6% of patients with special site involvement, and 81.8%\/63.6%\/54.6% of patients without special site involvement achieved PASI 75\/90\/100 response, and 87.5%, 94.3%, 97.0%, and 80.0% of patients, respectively, achieved PGA 0\/1 at the week 48. None of the differences among subgroups were statistically significant; however, patient numbers were too small to support robust conclusions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Tildrakizumab is effective for the treatment of moderate-to-severe plaque psoriasis in adults in a real-world setting in Canada.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/12034754241302827","type":"journal-article","created":{"date-parts":[[2024,12,14]],"date-time":"2024-12-14T06:51:08Z","timestamp":1734159068000},"page":"137-142","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Real-World Effectiveness of Tildrakizumab for Moderate-to-Severe Plaque Psoriasis in Canada"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9702-2086","authenticated-orcid":false,"given":"Mohannad","family":"Abu-Hilal","sequence":"first","affiliation":[{"name":"Division of Dermatology, McMaster University, Hamilton, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff","family":"Cowger","sequence":"additional","affiliation":[{"name":"Skin Therapy Centre, Advanced Medical Group, London, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Bawazir","sequence":"additional","affiliation":[{"name":"Falls Dermatology Centre, Niagara Falls, ON, Canada"},{"name":"Alliance Clinical Trials and Probity Medical Research, Inc., Waterloo, ON, Canada"},{"name":"Faculty of Health Sciences Department of Medicine, McMaster University, Waterloo, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dusan","family":"Sajic","sequence":"additional","affiliation":[{"name":"Alliance Clinical Trials and Probity Medical Research, Inc., Waterloo, ON, Canada"},{"name":"Faculty of Health Sciences Department of Medicine, McMaster University, Waterloo, ON, Canada"},{"name":"Guelph Dermatology Research, Guelph, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0413-3033","authenticated-orcid":false,"given":"Iryna","family":"Savinova","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belinda","family":"Yap","sequence":"additional","affiliation":[{"name":"Cencora, Innomar Strategies Inc., Oakville, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rami","family":"El-Sayegh","sequence":"additional","affiliation":[{"name":"Cencora, Innomar Strategies Inc., Oakville, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talshyn","family":"Bolatova","sequence":"additional","affiliation":[{"name":"Cencora, Innomar Strategies Inc., Oakville, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pak","family":"Chan","sequence":"additional","affiliation":[{"name":"Sun Pharma Canada Inc., Brampton, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4953-6411","authenticated-orcid":false,"given":"Ajith","family":"Cy","sequence":"additional","affiliation":[{"name":"Alliance Clinical Trials and Probity Medical Research, Inc., Waterloo, ON, Canada"},{"name":"Faculty of Health Sciences Department of Medicine, McMaster University, Waterloo, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,12,14]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.11.057"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13854"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.02.039"},{"issue":"4","key":"e_1_3_3_5_2","first-page":"278","article-title":"Diagnosis and management of psoriasis","volume":"63","author":"Kim WB","year":"2017","unstructured":"Kim WB, Jerome D, Yeung J. Diagnosis and management of psoriasis. Can Fam Physician. 2017;63(4):278-285.","journal-title":"Can Fam Physician"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14868"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-020-00578-0"},{"key":"e_1_3_3_8_2","unstructured":"Ilumya\u2122 (tildrakizumab) 100 mg\/mL for subcutaneous injection. Product Monograph. Sharjah UAE: Sun Pharmaceutical Industries Limited; 2022."},{"key":"e_1_3_3_9_2","unstructured":"ILUMYA\u00ae (tildrakizumab-asmn) injection for subcutaneous use. Full Prescribing Information. 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