{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T13:06:29Z","timestamp":1780664789248,"version":"3.54.1"},"reference-count":28,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Med Surg"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Acne is a widely prevalent disorder, with a largely negative impact on the patient\u2019s quality of life. Bacterial etiology and the role of\n                      <jats:italic toggle=\"yes\">Cutibacterium acne<\/jats:italic>\n                      have always been incriminated in in acne pathogenesis. However, in the last decade, deeper understanding of skin microbiome postulates a possible role of other pathogens like\n                      <jats:italic toggle=\"yes\">Malassezia<\/jats:italic>\n                      spp. ketoconazole has shown efficacy to both pathogens.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To study the efficacy of topical ketoconazole 2% in the treatment of acne vulgaris (AV) compared to the standard treatment with adapalene.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Fifty-eight acne patients in 2 groups were asked to blindly apply ketoconazole cream or adapalene gel to the face for 12\u2009weeks. Acne lesion count was performed at baseline, and at the end of the 12\u2009weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>At the end of the treatment period, both groups showed significantly similar improvement of comedones, papules, and pustules. Mild side effects were reported that were significantly less among the ketoconazole group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Topical ketoconazole 2% can provide very promising results as monotherapy in acne comparable to topical retinoid.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/12034754251386690","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T11:30:16Z","timestamp":1763119816000},"page":"220-226","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Antifungal Monotherapy in Acne: Topical Ketoconazole 2% Cream Versus Adapalene Gel in Treating Acne Vulgaris: A Comparative Study"],"prefix":"10.1177","volume":"30","author":[{"given":"Eman Mohamed","family":"Salah","sequence":"first","affiliation":[{"name":"Department of Dermatology, Andrology, Sexual Medicine and STDs, Faculty of Medicine, Helwan University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0162-5080","authenticated-orcid":false,"given":"Nermeen Ibrahim","family":"Bedair","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Andrology, Sexual Medicine and STDs, Faculty of Medicine, Helwan University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaa Sabri","family":"Farid","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Andrology, Sexual Medicine and STDs, Faculty of Medicine, Helwan University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3629-2749","authenticated-orcid":false,"given":"Manal Ahmed","family":"Sharara","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Andrology, Faculty of medicine, Ain Shams University, Cairo, 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