{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:53:55Z","timestamp":1791550435657,"version":"4.3.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100017785","name":"Pediatric Dermatology Research Alliance","doi-asserted-by":"publisher","award":["2024 Emerging Investigator Research Grant Program"],"award-info":[{"award-number":["2024 Emerging Investigator Research Grant Program"]}],"id":[{"id":"10.13039\/100017785","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Med Surg"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Hidradenitis suppurativa (HS) and pyoderma gangrenosum (PG) are chronic neutrophilic dermatoses characterized by dysregulated inflammation. Their coexistence in adults has been reported, but this has not been well documented in pediatric populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To characterize the overlap, clinical characteristics, and treatment options for pediatric patients with concurrent HS and PG.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted a retrospective case series of pediatric patients ages 3 to 17 with clinical diagnoses of HS and PG at The Hospital for Sick Children between January 2015 and January 2022. Demographic, clinical, laboratory, genetic, and treatment data were extracted from electronic medical records and analyzed descriptively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Seven of 122 pediatric HS patients (5.7%) had concurrent PG. HS onset preceded PG in all cases, with mean onset ages of 11.6 and 16.1\u2009years, respectively. The cohort had a slight male predominance (57%) and high rates of comorbidities, including obesity (71.4%) and acne conglobata (42.9%). Elevated erythrocyte sedimentation rate (ESR) (mean 56.9\u2009mm\/hour) was a significant predictor of HS severity (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.027). Three patients had autoinflammatory gene variants, and 57.1% met criteria for PASH or PAPA syndrome. Cytokine profiling revealed elevated IL-1\u03b2 and IL-6 in select cases. Three of 4 patients who underwent incision and drainage for HS developed PG at the surgical sites.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Pediatric patients with HS-PG may represent a distinct, severe inflammatory subset. Further investigation is needed to define risk factors, inflammatory biomarkers, and optimal treatment strategies in this rare overlap population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/12034754251386763","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T06:31:37Z","timestamp":1762324297000},"page":"139-142","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Concurrent Hidradenitis Suppurativa and Pyoderma Gangrenosum in a Pediatric Cohort: A Retrospective Case Series"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5030-777X","authenticated-orcid":false,"given":"Vince","family":"Wu","sequence":"first","affiliation":[{"name":"Division of Dermatology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada"},{"name":"Temerty School of Medicine, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3210-3413","authenticated-orcid":false,"given":"Irene","family":"Lara-Corrales","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9288-1121","authenticated-orcid":false,"given":"Cathryn","family":"Sibbald","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5407-3972","authenticated-orcid":false,"given":"Rebecca","family":"Levy","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,11,4]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2021.01.059"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2020.5435"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.04.001"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.19-3-224"},{"key":"e_1_3_3_6_2","unstructured":"Schmieder SJ Krishnamurthy K. Pyoderma gangrenosum. In: StatPearls. StatPearls Publishing; 2025. Accessed February 18 2025. http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK482223\/"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2010.328"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.856786"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/1203475419852049"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.02.004"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2021.2865"},{"key":"e_1_3_3_12_2","unstructured":"Ballard K Shuman VL. Hidradenitis suppurativa. In: StatPearls. StatPearls Publishing; 2025. Accessed March 3 2025. http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK534867\/"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1014163"},{"key":"e_1_3_3_14_2","unstructured":"Aksentijevich I Sampaio Moura N Barron K. Adenosine deaminase 2 deficiency. In: Adam MP Feldman J Mirzaa GM Pagon RA Wallace SE Amemiya A eds. GeneReviews\u00ae. University of Washington; 1993. Accessed March 3 2025. http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK544951\/"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15226"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.17031"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2017.03.013"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03444.x"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01900"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2016.07.007"}],"container-title":["Journal of Cutaneous Medicine and Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/12034754251386763","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/12034754251386763","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/12034754251386763","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:24:21Z","timestamp":1791548661000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/12034754251386763"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,4]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1177\/12034754251386763"],"URL":"https:\/\/doi.org\/10.1177\/12034754251386763","relation":{},"ISSN":["1203-4754","1615-7109"],"issn-type":[{"value":"1203-4754","type":"print"},{"value":"1615-7109","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,4]]}}}