{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T20:01:23Z","timestamp":1793131283245,"version":"4.5.0"},"reference-count":35,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Skin Investigation Network of Canada"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Med Surg"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Hidradenitis suppurativa (HS) is a highly comorbid condition understudied in pediatric populations. Furthermore, the underrepresentation of Canadians in HS research limits our evaluation of care in real-world Canadian settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To describe the demographics, clinical characteristics, psychosocial burden, and management of pediatric HS at a Canadian hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We developed the infrastructure for a Canada-wide HS registry and piloted it at a pediatric HS tertiary care centre. A retrospective review of patients seen was performed using data collection forms (DCFs) developed for the registry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The 39 patients included were 53.8% female and 100.0% nonsmokers. Asians were overrepresented compared to other North American studies. Most had Hurley stage II (60.5%) or III (28.9%) disease. Mean delay to diagnosis was 2.1\u2009\u00b1\u20092.0\u2009years. Obesity (57.9%), acne (30.7%), folliculitis (23.1%), and trisomy 21 (23.1%) were the most common comorbidities. Patients with trisomy 21 had an age of HS onset 3\u2009years younger (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.0087), and 44.0% had concomitant disseminate and recurrent infundibulofolliculitis. Moderate-to-severe quality of life (QOL) impact was seen in 56.8% of patients, and 17.6% had reported bullying. Of patients prescribed biologics (59.0%), most used 1 (56.6%), while 39.1% switched to a second and 4.3% to a third biologic. Most adalimumab-initiated patients clinically improved (81.0%), but only 2 patients achieved complete remission. Follow-up patients (n\u2009=\u200914) had significant improvements in QOL (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.038) and pain (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.026) scores.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Distinct demographics, severe disease, and low remission rates characterized our complex HS cohort. Prospective use of these DCFs will enhance our understanding of HS in Canada.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/12034754251404461","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T15:27:03Z","timestamp":1770910023000},"page":"353-362","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical Characteristics and Management of Pediatric Hidradenitis Suppurativa: A Canadian Single-Centre Multidisciplinary Experience"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5916-8201","authenticated-orcid":false,"given":"Serena","family":"Dienes","sequence":"first","affiliation":[{"name":"Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arya","family":"Rahmani","sequence":"additional","affiliation":[{"name":"Queen\u2019s School of Medicine, Queen\u2019s University, Kingston, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Lara-Corrales","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Pediatrics, The Hospital for Sick Children, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Levy","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Pediatrics, The Hospital for Sick Children, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raed","family":"Alhusayen","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine, University of Toronto, Toronto, ON, Canada"},{"name":"Sunnybrook Research Institute, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Barnett","sequence":"additional","affiliation":[{"name":"Independent Researcher"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Croitoru","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine, University of Toronto, Toronto, ON, Canada"},{"name":"Division of Dermatology, Toronto Western Hospital, Toronto, ON, Canada"},{"name":"Division of Dermatology, Women\u2019s College Hospital, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"George","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, The Hospital for Sick Children, Toronto, ON, Canada"},{"name":"Department of Pediatrics, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsti","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Nursing, The Hospital for Sick Children, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7469-5082","authenticated-orcid":false,"given":"Marissa","family":"Joseph","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Pediatrics, The Hospital for Sick Children, Toronto, ON, Canada"},{"name":"Division of Dermatology, Department of Medicine, University of Toronto, Toronto, ON, Canada"},{"name":"Division of Dermatology, Women\u2019s College Hospital, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Latoya","family":"Palmer","sequence":"additional","affiliation":[{"name":"Hidradenitis and Me Support Group, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Mirza","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, McMaster University, Hamilton, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6079-4517","authenticated-orcid":false,"given":"Vincent","family":"Piguet","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine, University of Toronto, Toronto, ON, Canada"},{"name":"Division of Dermatology, Women\u2019s College Hospital, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nimrita","family":"Sangha","sequence":"additional","affiliation":[{"name":"Department of Social Work, The Hospital for Sick Children, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Liy Wong","sequence":"additional","affiliation":[{"name":"Division of Dermatology and Rheumatology, Department of Pediatrics, Children\u2019s Hospital of Eastern Ontario, University of Ottawa, Ottawa, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9288-1121","authenticated-orcid":false,"given":"Cathryn","family":"Sibbald","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Pediatrics, The Hospital for Sick Children, Toronto, ON, Canada"},{"name":"Division of Dermatology, Department of Medicine, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,2,12]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2016.03.495"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/1203475420972348"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2021.1677"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2019.0478"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2021.01.059"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.08.045"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0000000000000253"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1497.2001.016009606.x"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.10.1092"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/003591576906201005"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1553-2712.2009.00620.x"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12645"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2020.5435"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/pde.14326"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/pde.14765"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.19435"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10112973"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15071"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15507"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/pde.15891"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.04.001"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.20581"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/jvc2.70065"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.162"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1177\/1203475419852049"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.04.045"},{"key":"e_1_3_2_28_2","first-page":"293","article-title":"The \u201cgene dosage effect\u201d hypothesis versus the \u201camplified developmntal instability\u201d hypothesis in Down syndrome","volume":"57","author":"Pritchard M","year":"1999","unstructured":"Pritchard M, The KI. The \u201cgene dosage effect\u201d hypothesis versus the \u201camplified developmntal instability\u201d hypothesis in Down syndrome. J Neural Transm Suppl. 1999;57:293-303.","journal-title":"J Neural Transm Suppl"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12887"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1078\/0171-9335-00401"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.5826\/dpc.0903a03"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1159\/000514363"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02466-4"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40259-024-00687-w"},{"issue":"1","key":"e_1_3_2_35_2","first-page":"53","article-title":"The use of fecal calprotectin in inflammatory Bowel disease","volume":"13","author":"Bjarnason I.","year":"2017","unstructured":"Bjarnason I. The use of fecal calprotectin in inflammatory Bowel disease. Gastroenterol Hepatol (N Y). 2017;13(1):53-56.","journal-title":"Gastroenterol Hepatol (N Y)"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/pde.14417"}],"container-title":["Journal of Cutaneous Medicine and Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/12034754251404461","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/12034754251404461","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/12034754251404461","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T12:11:58Z","timestamp":1787141518000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/12034754251404461"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,12]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1177\/12034754251404461"],"URL":"https:\/\/doi.org\/10.1177\/12034754251404461","relation":{},"ISSN":["1203-4754","1615-7109"],"issn-type":[{"value":"1203-4754","type":"print"},{"value":"1615-7109","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,12]]}}}