{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T12:31:51Z","timestamp":1787142711575,"version":"build-2736575974"},"reference-count":18,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Med Surg"],"published-print":{"date-parts":[[2026,7]]},"abstract":"\n Background:<\/jats:title>\n Psoriasis is a systemic inflammatory disease associated with cardiopulmonary comorbidities. Nail psoriasis, quantified by the Nail Psoriasis Severity Index (NAPSI), is a marker of severe disease. While pulmonary arterial hypertension (PAH) is reported more frequently in psoriasis, the specific correlation between nail psoriasis severity and PAH remains underexplored.<\/jats:p>\n <\/jats:sec>\n \n Objective:<\/jats:title>\n To investigate the correlation between NAPSI scores and the presence or severity of PAH in patients with psoriasis.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n A prospective, cross-sectional study was conducted at a tertiary care centre involving 100 patients with chronic plaque psoriasis (50 with and 50 without nail psoriasis). All participants underwent dermatological evaluation [Psoriasis Area and Severity Index (PASI) and NAPSI scoring], transthoracic echocardiography to estimate pulmonary artery systolic pressure (PASP), and measurement of inflammatory markers [C-reactive protein (CRP), IL-17, TNF-\u03b1]. PAH was defined as PASP\u2009>\u200935\u2009mmHg. Statistical analyses included correlation tests, comparative analyses, and multivariate logistic regression.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n PAH was identified in 29% (n\u2009=\u200929) of patients, with a significantly higher prevalence in the nail psoriasis group (40% vs 18%,\n P<\/jats:italic>\n \u2009=\u2009.01). Patients with PAH had higher mean NAPSI scores than those without (29.5\u2009\u00b1\u200913.4 vs 18.2\u2009\u00b1\u200910.6,\n P<\/jats:italic>\n \u2009=\u2009.001). A moderate positive correlation was found between NAPSI scores and PASP (\n r<\/jats:italic>\n \u2009=\u20090.44,\n P<\/jats:italic>\n \u2009<\u2009.001). PASI scores and CRP levels were also significantly elevated in patients with PAH and correlated with PASP (\n r<\/jats:italic>\n \u2009=\u20090.38,\n P<\/jats:italic>\n \u2009=\u2009.001 and\n r<\/jats:italic>\n \u2009=\u20090.41,\n P<\/jats:italic>\n \u2009<\u2009.001, respectively).Multivariate analysis confirmed NAPSI score as an independent predictor of PAH [odds ratio (OR): 1.07\/unit increase, 95% CI: 1.03-1.11,\n P<\/jats:italic>\n \u2009=\u2009.002], after adjusting for confounders including PASI score and comorbidities. PASI (OR: 1.05,\n P<\/jats:italic>\n \u2009=\u2009.01) and CRP (OR: 1.13,\n P<\/jats:italic>\n \u2009=\u2009.008) were also independent predictors. Nail matrix involvement was more strongly associated with PAH than nail bed involvement (\n P<\/jats:italic>\n \u2009=\u2009.03). Inflammatory markers (CRP, IL-17, TNF-\u03b1) were significantly elevated in patients with PAH.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n NAPSI scores, PASI scores, and CRP levels are all significantly correlated with and independently predict PAH in patients with psoriasis. Assessment of nail psoriasis severity may serve as a valuable, noninvasive clinical tool to identify psoriasis patients at increased risk of pulmonary vascular complications, warranting further cardiological evaluation.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/12034754251408375","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T04:13:52Z","timestamp":1768277632000},"page":"339-345","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Do Nails Tell a Pulmonary Tale? A Cross-Sectional Study on Psoriasis and Pulmonary Hypertension Risk"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1054-1738","authenticated-orcid":false,"given":"Sharang","family":"Gupta","sequence":"first","affiliation":[{"name":"Department of Dermatology, Civil Hospital, Nabha, Patiala, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimple","family":"Chopra","sequence":"additional","affiliation":[{"name":"Department of Dermatology,Government Medical College, Patiala, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,1,12]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.339"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.08.015"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-008-0859-9"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/508178"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-016-0564-5"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1067\/s0190-9622(03)00910-1"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09831.x"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.135470"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12368"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2010.05.010"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv317"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.02.040"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03364.x"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2011.01261.x"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.7812\/TPP\/16-073"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12355"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.365"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.918224"}],"container-title":["Journal of Cutaneous Medicine and Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/12034754251408375","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/12034754251408375","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/12034754251408375","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T12:11:41Z","timestamp":1787141501000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/12034754251408375"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,12]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1177\/12034754251408375"],"URL":"https:\/\/doi.org\/10.1177\/12034754251408375","relation":{},"ISSN":["1203-4754","1615-7109"],"issn-type":[{"value":"1203-4754","type":"print"},{"value":"1615-7109","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,12]]}}}