{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T17:01:08Z","timestamp":1785085268436,"version":"3.55.0"},"reference-count":24,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Med Surg"],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Literature on onychomycosis prevalence, causative agents, and systemic antifungal treatment efficacy in psoriasis are sparse.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The objectives of the study were to determine onychomycosis prevalence in psoriasis patients with nail changes and to evaluate the efficacy and safety of 2 systemic antifungal treatments, terbinafine, and fluconazole.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Records from the Division of Dermatology at Rabin Medical Center (2012-2022), were retrospectively analyzed, including nail samples from consecutive psoriasis patients referred to the institutional mycological laboratory.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      One hundred thirty-nine psoriasis patients with suspected onychomycosis were referred for mycological testing (46.8% female, median age 62\u2009years), onychomycosis was diagnosed in 67.6% of cases. Fifty-one point one percent of patients were on systemic psoriasis treatments, 60.6% of them receiving biologic therapies.\n                      <jats:italic toggle=\"yes\">Trichophyton rubrum<\/jats:italic>\n                      was the most prevalent (81.3%) isolated fungi of all positive cultures. Fifty-one patients received systemic antifungal treatment, with 47.1% receiving terbinafine and 52.9% fluconazole. Clinical improvement was observed in 70.8% of terbinafine-treated cases and 40.7% of fluconazole-treated cases (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.002). No psoriasis flare-ups were attributed to systemic antifungal treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This cohort provides insights into prevalence of onychomycosis, and the efficacy and safety of systemic antifungal treatment in psoriasis patients, including patients on biologic therapies. Further prospective studies are recommended.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/12034754261467038","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T05:34:34Z","timestamp":1784871274000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnosis and Treatment of Onychomycosis in Psoriasis Patients: A Single-Center Cohort Study"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9749-9395","authenticated-orcid":false,"given":"Noa","family":"Zur Aviran","sequence":"first","affiliation":[{"name":"Division of Dermatology, Rabin Medical Center, Petah Tikva, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Berkovich Davidson","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Rabin Medical Center, Petah Tikva, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shany","family":"Sherman","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Rabin Medical Center, Petah Tikva, Israel"},{"name":"Gray Faculty of Medicine, Tel Aviv University, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Mimouni","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Rabin Medical Center, Petah Tikva, Israel"},{"name":"Gray Faculty of Medicine, Tel Aviv University, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lev","family":"Pavlovsky","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Rabin Medical Center, Petah Tikva, Israel"},{"name":"Gray Faculty of Medicine, Tel Aviv University, 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