{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T07:54:27Z","timestamp":1790927667595,"version":"4.1.0"},"reference-count":29,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Med Surg"],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease associated with multiple systemic comorbidities. Although its association with type 2 diabetes is well established, the clinical impact of coexisting type 1 diabetes (T1D) remains poorly defined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To compare the clinical characteristics, disease burden, and therapeutic requirements of patients with HS and T1D with matched HS controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted a multicenter retrospective matched case-control study across 3 tertiary dermatology departments. Patients with HS and confirmed T1D were matched 1:3 by age, sex, and baseline Hurley stage. Clinical and therapeutic outcomes were assessed over a standardized 48\u2009week follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Twelve patients with HS and T1D and 33 matched controls were included. Baseline disease severity was comparable. During follow-up, patients with HS\u2009+\u2009T1D had higher mean International Hidradenitis Suppurativa Severity Score System scores (11.95 vs 6.24;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.01), more draining tunnels (11.0 vs 3.97;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.01), received more systemic treatments (4.10 vs 3.06;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.03), and underwent more surgical procedures (1.67 vs 0.67;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Patients with HS and coexisting T1D may experience a greater inflammatory and therapeutic burden than matched controls. These findings support closer multidisciplinary management and warrant prospective studies to validate T1D as a potential modifier of HS severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Limitations:<\/jats:title>\n                    <jats:p>Retrospective design and small sample size.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/12034754261484189","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T08:56:24Z","timestamp":1790585784000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Type 1 Diabetes is Associated With Increased Therapeutic Burden in Hidradenitis Suppurativa: A Multicenter Retrospective Matched Case-Control Study"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2304-0114","authenticated-orcid":false,"given":"Irene","family":"Rivera-Ruiz","sequence":"first","affiliation":[{"name":"Dermatology Department, Hospital Universitario Reina Sof\u00eda, C\u00f3rdoba, Spain"},{"name":"Inflammatory Immune-Mediated Chronic Skin Diseases Laboratory (GC29), Maimonides Biomedical Research Institute of C\u00f3rdoba (IMIBIC), Reina Sof\u00eda University Hospital, University of C\u00f3rdoba, Spain"},{"name":"Dermatology Department, Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Soto-Moreno","sequence":"additional","affiliation":[{"name":"Hidradenitis Suppurativa Unit, Dermatology Department, Hospital Universitario Virgen de las Nieves, Granada, Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria IBS, Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6730-6723","authenticated-orcid":false,"given":"Miguel","family":"Mansilla-Polo","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital Universitario y Polit\u00e9cnico La Fe, Valencia, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria La Fe (IIS La Fe), Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3325-6785","authenticated-orcid":false,"given":"Patricia","family":"Garbayo-Salmons","sequence":"additional","affiliation":[{"name":"Dermatology Department, Parc Taul\u00ed Hospital Universitari, Sabadell, Barcelona, Spain"},{"name":"Institut d\u2019Investigaci\u00f3 i Innovaci\u00f3 Parc Taul\u00ed (I3PT-CERCA), Universitat Aut\u00f2noma de Barcelona, Sabadell, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Mu\u00f1oz-Barba","sequence":"additional","affiliation":[{"name":"Hidradenitis Suppurativa Unit, Dermatology Department, Hospital Universitario Virgen de las Nieves, Granada, Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria IBS, Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9sar","family":"Guijarro-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital Universitario Reina Sof\u00eda, C\u00f3rdoba, Spain"},{"name":"Dermatology Department, Hospital Universitario General de Villalba, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Molina-Leyva","sequence":"additional","affiliation":[{"name":"Hidradenitis Suppurativa Unit, Dermatology Department, Hospital Universitario Virgen de las Nieves, Granada, Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria IBS, Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)02475-9"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/BJD\/LJAD345"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/BJD.19556"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS242317014"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/JAMADERMATOL.2014.1165"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.CLINDERMATOL.2017.09.007"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/BJD.13777"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.JAAD.2017.08.042"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.JAAD.2018.01.014"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS24076596"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/FIMMU.2017.01898"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0161548"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0142976"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/S41598-024-73737-6"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.2337\/DC14-1720"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61602-X"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/JDV.20472"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.2337\/DC25-S002"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/BJD.17508"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/BJD.15748"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.3390\/JCM10163648"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/JDV.16183"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/CEI.13449"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.3390\/JCM13175211"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/DOM.16460"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/JDV.16642"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.3390\/JCM14082625"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1001\/JAMADERMATOL.2020.1281"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.3389\/FIMMU.2020.594735"}],"container-title":["Journal 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