{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T01:37:52Z","timestamp":1777513072420,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Med Surg"],"published-print":{"date-parts":[[1998,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Offspring resulting from consanguineous marriages have been important in advancing research in genodermatoses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The concepts of consanguinity and inbreeding are reviewed and their contributions to research in hereditary skin diseases explained.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Examples are given in which inbred individuals with hereditary skin disease have increased our knowledge of skin disease genetics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>An enhanced understanding of the genetics of xeroderma pigmentosum, lamellar ichthyosis, and Werner's syndrome, among others, has arisen from the observation of populations and families in which inbreeding has occurred.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Populations practicing inbreeding and consanguineous marriages in generally outbred populations have provided important observations for determining the inheritance pattern of several genodermatoses and for identifying the responsible genes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/120347549800200311","type":"journal-article","created":{"date-parts":[[2017,7,9]],"date-time":"2017-07-09T19:44:58Z","timestamp":1499629498000},"page":"168-171","source":"Crossref","is-referenced-by-count":1,"title":["Geneticists Share the Family Jewels: How Inbreeding Has Contributed to Understanding Hereditary Skin Disease"],"prefix":"10.1177","volume":"2","author":[{"given":"Sherri J.","family":"Bale","sequence":"first","affiliation":[{"name":"Genetic Studies Section, LSB, NIAMS, Bethesda, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1998,1,1]]},"reference":[{"key":"bibr1-120347549800200311","doi-asserted-by":"publisher","DOI":"10.1038\/ng1094-117"},{"key":"bibr2-120347549800200311","doi-asserted-by":"publisher","DOI":"10.1159\/000247092"},{"key":"bibr3-120347549800200311","doi-asserted-by":"publisher","DOI":"10.1007\/BF00278288"},{"key":"bibr4-120347549800200311","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1987.01660260111026"},{"key":"bibr5-120347549800200311","first-page":"303","volume":"123","author":"Boudjar B","year":"1996","journal-title":"Ann Dermatol Ven\u00e9reol"},{"key":"bibr6-120347549800200311","first-page":"306","volume":"115","author":"McKusick VA","year":"1964","journal-title":"Bull Johns Hopkins Hosp"},{"key":"bibr7-120347549800200311","first-page":"374","volume-title":"Smith's recognizable patterns of human malformations","author":"Jones 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Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/120347549800200311","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/120347549800200311","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:46:56Z","timestamp":1777391216000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/120347549800200311"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,1]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1998,1]]}},"alternative-id":["10.1177\/120347549800200311"],"URL":"https:\/\/doi.org\/10.1177\/120347549800200311","relation":{},"ISSN":["1203-4754","1615-7109"],"issn-type":[{"value":"1203-4754","type":"print"},{"value":"1615-7109","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,1]]}}}