{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T01:54:58Z","timestamp":1777514098595,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[1999,10,1]],"date-time":"1999-10-01T00:00:00Z","timestamp":938736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Med Surg"],"published-print":{"date-parts":[[1999,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Mouse models of human diseases help identify gene defects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The methods of homozygosity mapping and mouse\/human homology to identify genes are reviewed. The genotype\/phenotype correlation in two clinical entities with mutations in the human hairless gene are discussed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The example of the hairless mouse's contribution to our knowledge of hereditary alopecia is used, and the utility of consanguineous families for genetic studies is highlighted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Mutations in the human homolog of the mouse hairless gene lead to congenital alopecia universalis and atrichia with papules.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>A mouse model of congenital alopecia has led to understanding the molecular basis of at least one type of severe human alopecia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/120347549900300607","type":"journal-article","created":{"date-parts":[[2017,7,10]],"date-time":"2017-07-10T15:48:09Z","timestamp":1499701689000},"page":"309-311","source":"Crossref","is-referenced-by-count":4,"title":["Of\n                    <i>Hairless<\/i>\n                    Mice and Men: The Genetic Basis of Congenital Alopecia Universalis\/Congenital Atrichia"],"prefix":"10.1177","volume":"3","author":[{"given":"Sherri J.","family":"Bale","sequence":"first","affiliation":[{"name":"Genetic Studies Section, LSB, National Institute of Arthritis & Musculoskeletal & Skin Disease, National Institutes of Health, Bethesda, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1999,10,1]]},"reference":[{"key":"bibr1-120347549900300607","unstructured":"Rook A, Dawber K. 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