{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:55:52Z","timestamp":1793728552527,"version":"4.6.1"},"reference-count":22,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2000,12,1]],"date-time":"2000-12-01T00:00:00Z","timestamp":975628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2000,12]]},"abstract":"<jats:p>Visual impairment is one of the most common clinical manifestations of Multiple Sclerosis (MS), and is strongly related to overall health-related quality of life (HRQOL) in MS and other disorders. However, the assessment of vision-specific HRQOL in patients with MS has been limited. The purpose of this study was to examine self-reported visual dysfunction in a clinically heterogeneous MS cohort using the 25-Item National Eye Institute Visual Function Questionnaire (VFQ-25). The VFQ-25 was administered by telephone interview to a subset of participants in a follow-up study to a phase III trial of interferon \u03b2-1a for relapsing-remitting MS. Mean VFQ-25 composite scores and selected sub-scale scores were significantly lower (worse) among patients in our MS cohort (n=35) compared with a published reference group of patients with no history of chronic eye disease (n=118). These differences were observed despite a relatively younger age and tighter distribution of binocular visual acuities in the MS cohort. Patients with MS in this study thus demonstrated a greater degree of self-reported visual dysfunction, as measured by the VFQ-25, compared with an eye disease-free reference group. The VFQ-25 is a potentially useful measure of vision-specific HRQOL in patients with MS.<\/jats:p>","DOI":"10.1177\/135245850000600604","type":"journal-article","created":{"date-parts":[[2007,1,18]],"date-time":"2007-01-18T20:03:56Z","timestamp":1169150636000},"page":"382-385","source":"Crossref","is-referenced-by-count":41,"title":["Self-reported visual dysfunction in multiple sclerosis: results from the                 25-Item National Eye Institute Visual Function Questionnaire (VFQ-25)"],"prefix":"10.1177","volume":"6","author":[{"given":"Laura J","family":"Balcer","sequence":"first","affiliation":[{"name":"Department of Neurology, University of Pennsylvania School of Medicine,                         Philadelphia, Pennsylvania, USA, Department of Ophthalmology, University of                         Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika L","family":"Baier","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, AMC Cancer Research Center, Denver,                         Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy M","family":"Kunkle","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Pennsylvania School of Medicine,                         Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A","family":"Rudick","sequence":"additional","affiliation":[{"name":"Department of Neurology, Cleveland Clinic Foundation, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca","family":"Weinstock-Guttman","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Buffalo, Buffalo, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Simonian","sequence":"additional","affiliation":[{"name":"Biogen, Fourteen Cambridge Center, Cambridge, Massachusetts, MA 02142, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven L","family":"Galetta","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Pennsylvania School of Medicine,                         Philadelphia, Pennsylvania, USA, Department of Ophthalmology, University of                         Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary R","family":"Cutter","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, AMC Cancer Research Center, Denver,                         Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen G","family":"Maguire","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Pennsylvania School of                         Medicine, Philadelphia, Pennsylvania, USA, Department of Biostatistics,                         University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2000,12,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.9.747"},{"key":"atypb2","first-page":"180","volume":"2","author":"Warner J","year":"1994","journal-title":"Clin Neurosci"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1968.tb07444.x"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.3.473"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1159\/000309813"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/100.3.563"},{"key":"atypb7","first-page":"5539","volume-title":"Walsh and Hoyt's Clinical Neuro-Ophthalmology","author":"Newman NJ.","year":"1998","edition":"5"},{"key":"atypb8","first-page":"1017","volume":"41","author":"Cole SR","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1992.00530360035014"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1177\/135245859900500410"},{"key":"atypb11","unstructured":"Mangione CM. 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