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However, C. pneumoniae-specific IgG titers were significantly higher in CSF of MS than in controls. Sixteen out of 52 seropositive MS patients (30.8%) showed intrathecal synthesis of C. pneumoniae-specific IgG but only one of 43 seropositive controls (2.3%). In MS, this was strongly associated with intrathecal synthesis of polyclonal IgG in 13\/16 patients. However, these elevated C. pneumoniae antibody titers in CSF did not significantly correlate with disease duration, disease course, clinical or MRI disease activity, disability or presence of oligoclonal IgG in MS.<\/jats:p>","DOI":"10.1177\/135245850100700103","type":"journal-article","created":{"date-parts":[[2007,1,18]],"date-time":"2007-01-18T20:03:56Z","timestamp":1169150636000},"page":"13-18","source":"Crossref","is-referenced-by-count":15,"title":["Chlamydia pneumoniae in multiple sclerosis: humoral immune responses in serum                 and cerebrospinal fluid and correlation with disease activity marker"],"prefix":"10.1177","volume":"7","author":[{"given":"D","family":"Krametter","sequence":"first","affiliation":[{"name":"Department of Neurology, Karl-Franzens-Universit\u00e1t, Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Niederwieser","sequence":"additional","affiliation":[{"name":"Department of Neurology, Barmherzige 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