{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:09:07Z","timestamp":1777936147395,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:p>Introduction and objectives Female sexual dysfunction (FSD) is highly prevalent (45\u201374%) in multiple sclerosis (MS) patients. Quantitative sensory testing (QST) has recently been used to assess normal neural function of the female genitalia. In this study we used QST for assessment of the genital neural function of female MS patients.<\/jats:p>\n                  <jats:p>Materials and methods We examined 41 female MS patients aged 21\u201356, with 10 years median disease duration. Each patient had a neurological examination, and evaluation of sexual function (SF) by both questionnaire and a focused interview. QST wasperformed at the clitoris and vagina for temperature and vibratory stimuli, by method of limits.<\/jats:p>\n                  <jats:p>Results By questionnaire, 25 patients (61%) had FSD; the most common complaints were decreased libido (61%) and orgasmic disturbances (54%). Sensory deficit was very common\u2013significant correlations were found between high sensory thresholds and FSD parameters; the most significant correlation was between clitoral vibratory sensation and orgasmic dysfunction (r=0.423, P=0.006). Another interesting significant association was found between cerebellar deficit and orgasmic dysfunction (P=0.0012).<\/jats:p>\n                  <jats:p>Conclusions This study suggests that QST of the genitalia, specifically clitoral vibration, may be a useful test for detecting sexual dysfunction in MS patients, and supports an important role of the cerebellum in SF.<\/jats:p>","DOI":"10.1177\/1352458506071134","type":"journal-article","created":{"date-parts":[[2007,1,17]],"date-time":"2007-01-17T09:38:29Z","timestamp":1169026709000},"page":"95-105","source":"Crossref","is-referenced-by-count":64,"title":["Sexual dysfunction in females with multiple sclerosis: quantitative sensory testing"],"prefix":"10.1177","volume":"13","author":[{"given":"Ilan","family":"Gruenwald","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoram","family":"Vardi","sequence":"additional","affiliation":[{"name":"Rappaport School of medicine, Technion, Haifa, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irena","family":"Gartman","sequence":"additional","affiliation":[{"name":"Neuro-urology Unit, Rambam Medical Center, Haifa, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Juven","sequence":"additional","affiliation":[{"name":"Rappaport School of medicine, Technion, Haifa, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elliot","family":"Sprecher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Yarnitsky","sequence":"additional","affiliation":[{"name":"Rappaport School of medicine, Technion, Haifa, Israel; Neurology Department, Rambam Medical Center, Haifa, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariel","family":"Miller","sequence":"additional","affiliation":[{"name":"Rappaport School of medicine, Technion, Haifa, Israel; Multiple Sclerosis Center, Carmel Medical Center, Haifa, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2007,1,1]]},"reference":[{"key":"atypb1","first-page":"45","volume":"5","author":"Ghezzi A.","year":"1998","journal-title":"Int MS Journal"},{"key":"atypb2","first-page":"418","volume":"6","author":"Zorzon M","year":"1999","journal-title":"Mult Scler"},{"key":"atypb3","first-page":"125","volume":"65","author":"Valleroy ML","year":"1984","journal-title":"Arch Phys Med Rehabil"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.59.1.83"},{"key":"atypb5","first-page":"1","volume":"4","author":"Foley FW","year":"1997","journal-title":"Mult Scler Manag"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-005-0891-6"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1177\/135245850100700404"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1191\/1352458504ms1060oa"},{"key":"atypb9","first-page":"4","volume":"6","author":"Foley F","year":"2005","journal-title":"MS in Focus"},{"key":"atypb10","first-page":"385","volume":"32","author":"Heijenbrok MW","year":"1992","journal-title":"Electromyogr Clin Neurophysiol"},{"key":"atypb11","first-page":"119","volume":"33","author":"Merchut MP","year":"1993","journal-title":"Electro-myogr Clin Neurophysiol"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(00)00850-5"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)66941-8"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410130302"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1002\/ana.1032"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.33.11.1444"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000194255.82542.6b"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1080\/009262300278597"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1097\/00019052-200206000-00008"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.4.928"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/121.4.561"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458506071134","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458506071134","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:21:05Z","timestamp":1777692065000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1352458506071134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["10.1177\/1352458506071134"],"URL":"https:\/\/doi.org\/10.1177\/1352458506071134","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1]]}}}