{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T17:30:34Z","timestamp":1762623034840,"version":"3.38.0"},"reference-count":37,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:p> Backgrounds Atrophy of corpus callosum (CC), a white matter structure linking the two hemispheres, is commonly observed in multiple sclerosis (MS). However, the occurrence and processes leading to this alteration are not yet determined. <\/jats:p><jats:p> Goal and methods To better characterize the onset and progression of CC atrophy from the early stage of MS, we performed a two-year follow-up magnetic resonance imaging\/magnetic resonance spectroscopic imaging (MRI\/MRSI) exploration of CC in 24 patients with clinically isolated syndrome. These patients were explored using the same protocol at month (M)6, M12 and M24. MRI\/MRSI techniques were applied to measure CC volume, and relative concentrations of N-acetylaspartate (NAA), creatine\/phosphocreatine (Cr) and choline-containing compounds (Cho). A group of matched controls was also explored. <\/jats:p><jats:p> Results Atrophy of CC, not present at baseline, was observed at M12 and progressed over the second year (M24). At baseline, a decrease in relative NAA level was observed in the anterior and posterior body of CC, with normalization during the follow-up period. In the anterior body, an increase in relative Cho level was observed, with normalization at M6. Normal relative Cr levels were observed at all time points in all sub-regions. The rate of CC atrophy was correlated with the change in the Expanded Disability Status Scale (EDSS) during the follow-up period. <\/jats:p><jats:p> Conclusion These results suggest that CC atrophy appears over a period of one year after the first acute inflammatory episode, and that this atrophy is accompanied, especially in the anterior body of CC, by a normalization of the relative Cho levels, marker of acute inflammation, and NAA levels, marker of neuronal dysfunction and\/or loss. <\/jats:p>","DOI":"10.1177\/1352458506071215","type":"journal-article","created":{"date-parts":[[2007,1,17]],"date-time":"2007-01-17T14:38:29Z","timestamp":1169044709000},"page":"41-51","source":"Crossref","is-referenced-by-count":48,"title":["Onset and underpinnings of white matter atrophy at the very early stage of                 multiple sclerosis - a two-year longitudinal MRI\/MRSI study of corpus callosum"],"prefix":"10.1177","volume":"13","author":[{"given":"B","family":"Audoin","sequence":"first","affiliation":[{"name":"Centre de R\u00e9sonance Magn\u00e9tique Biologique et                         M\u00e9dicale - UMR CNRS 6612 - Facult\u00e9 de                         M\u00e9decine, Universit\u00e9 de la                         M\u00e9diterran\u00e9e, Marseille 13385, France; Service de                         Neurologie, CHU Timone, Marseille 13005, France"}]},{"given":"D","family":"Ibarrola","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9sonance Magn\u00e9tique Biologique et                         M\u00e9dicale - UMR CNRS 6612 - Facult\u00e9 de                         M\u00e9decine, Universit\u00e9 de la                         M\u00e9diterran\u00e9e, Marseille 13385, France"}]},{"given":"I","family":"Malikova","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9sonance Magn\u00e9tique Biologique et                         M\u00e9dicale - UMR CNRS 6612 - Facult\u00e9 de                         M\u00e9decine, Universit\u00e9 de la                         M\u00e9diterran\u00e9e, Marseille 13385, France; Service de                         Neurologie, CHU Timone, Marseille 13005, France"}]},{"given":"E","family":"Soulier","sequence":"additional","affiliation":[]},{"given":"S","family":"Confort-Gouny","sequence":"additional","affiliation":[]},{"given":"M-V Au","family":"Duong","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9sonance Magn\u00e9tique Biologique et                         M\u00e9dicale - UMR CNRS 6612 - Facult\u00e9 de                         M\u00e9decine, Universit\u00e9 de la                         M\u00e9diterran\u00e9e, Marseille 13385, France"}]},{"given":"F","family":"Reuter","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9sonance Magn\u00e9tique Biologique et                         M\u00e9dicale - UMR CNRS 6612 - Facult\u00e9 de                         M\u00e9decine, Universit\u00e9 de la                         M\u00e9diterran\u00e9e, Marseille 13385, France; Service de                         Neurologie, CHU Timone, Marseille 13005, France"}]},{"given":"P","family":"Viout","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9sonance Magn\u00e9tique Biologique et                         M\u00e9dicale - UMR CNRS 6612 - Facult\u00e9 de                         M\u00e9decine, Universit\u00e9 de la                         M\u00e9diterran\u00e9e, Marseille 13385, France"}]},{"given":"A","family":"Ali-Ch\u00e9rif","sequence":"additional","affiliation":[{"name":"Service de Neurologie, CHU Timone, Marseille 13005, France"}]},{"given":"P J","family":"Cozzone","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9sonance Magn\u00e9tique Biologique et                         M\u00e9dicale - UMR CNRS 6612 - Facult\u00e9 de                         M\u00e9decine, Universit\u00e9 de la                         M\u00e9diterran\u00e9e, Marseille 13385, France"}]},{"given":"J","family":"Pelletier","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9sonance Magn\u00e9tique Biologique et                         M\u00e9dicale - UMR CNRS 6612 - Facult\u00e9 de                         M\u00e9decine, Universit\u00e9 de la                         M\u00e9diterran\u00e9e, Marseille 13385, France; Service de                         Neurologie, CHU Timone, Marseille 13005, France"}]},{"given":"J-P","family":"Ranjeva","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9sonance Magn\u00e9tique Biologique et                         M\u00e9dicale - UMR CNRS 6612 - Facult\u00e9 de                         M\u00e9decine, Universit\u00e9 de la                         M\u00e9diterran\u00e9e, Marseille 13385, France"}]}],"member":"179","published-online":{"date-parts":[[2007,1,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1191\/1352458504ms1050oa"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/119.6.2009"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000036271.49066.06"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.8.1698"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000154526.22878.30"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1191\/1352458503ms938oa"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1002\/ana.1032"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.33.11.1444"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2594(200002)43:2<211::AID-MRM7>3.0.CO;2-A"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1016\/0730-725X(94)90086-7"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2594(199904)41:4<649::AID-MRM2>3.0.CO;2-G"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.58.1.105"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1993.00540100066018"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1006\/jmre.1997.1244"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1191\/1352458503ms868oa"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000055926.69643.03"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.59.10.1572"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.214.3.r00mr30665"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(00)00259-8"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-004-0349-8"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.59.1.126"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2203001776"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh126"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.58.1.115"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.5.1091"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(99)00105-7"},{"key":"atypb27","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh153"},{"key":"atypb28","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/122.10.1933"},{"key":"atypb29","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/117.1.49"},{"key":"atypb30","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410310302"},{"key":"atypb31","doi-asserted-by":"publisher","DOI":"10.1007\/s004150170052"},{"key":"atypb32","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(96)00182-8"},{"key":"atypb33","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2003.11.001"},{"key":"atypb34","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910290605"},{"key":"atypb35","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(89)90144-5"},{"key":"atypb36","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2004.039032"},{"key":"atypb37","first-page":"1081","volume":"61","author":"Oh J","year":"2004","journal-title":"Arch Neurol"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458506071215","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458506071215","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T23:03:29Z","timestamp":1740956609000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1352458506071215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["10.1177\/1352458506071215"],"URL":"https:\/\/doi.org\/10.1177\/1352458506071215","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"type":"print","value":"1352-4585"},{"type":"electronic","value":"1477-0970"}],"subject":[],"published":{"date-parts":[[2007,1]]}}}