{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:09:17Z","timestamp":1777936157786,"version":"3.51.4"},"reference-count":6,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:p>We describe retrospective data from the largest series of patients (n=142) with multiple sclerosis (MS) from Pakistan. Mean age at onset was 27 years, with a female to male ratio of 1.45:1. The disease onset was polysymptomatic in 75% patients. Motor weakness was the most common onset symptom (70%), followed by sensory symptoms (45%). Optico-spinal type of MS was seen in only 3% of patients The courzse was relapsing-remitting (RR) in 81%, primary progressive (PP) in 21%, and secondary progressive (SP) in 4% of patients. Almost three-fourths of the patients were moderately (45%) or severely (31%) disabled at the time of evaluation. Two-thirds of patients with severe disability had a mean disease duration of only 5.2 years. In conclusion, MS is not uncommon in Pakistan, and many patients were found to have severe disability despite short disease duration. Multiple Sclerosis 2007; 13: 668-669. http:\/\/msj.sagepub.com<\/jats:p>","DOI":"10.1177\/1352458506072339","type":"journal-article","created":{"date-parts":[[2007,2,9]],"date-time":"2007-02-09T20:28:08Z","timestamp":1171052888000},"page":"668-669","source":"Crossref","is-referenced-by-count":17,"title":["Multiple sclerosis in Pakistan"],"prefix":"10.1177","volume":"13","author":[{"given":"M.","family":"Wasay","sequence":"first","affiliation":[{"name":"The Aga Khan University, Karachi, Pakistan,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Ali","sequence":"additional","affiliation":[{"name":"Jinnah Post Graduate Medical Center, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.A.","family":"Khatri","sequence":"additional","affiliation":[{"name":"Liaquat National Hospital, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Hassan","sequence":"additional","affiliation":[{"name":"Shifa International Hospital, Islamabad, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Asif","sequence":"additional","affiliation":[{"name":"Baqai Medical University, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Zakiullah","sequence":"additional","affiliation":[{"name":"The Aga Khan University, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Shifa International Hospital, Islamabad, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Malik","sequence":"additional","affiliation":[{"name":"Jinnah Post Graduate Medical Center, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Khealani","sequence":"additional","affiliation":[{"name":"The Aga Khan University, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Haq","sequence":"additional","affiliation":[{"name":"Al-Aman Hospital, Peshawar, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Fredrikson","sequence":"additional","affiliation":[{"name":"Karolinska Institute, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2007,6,1]]},"reference":[{"key":"atypb1","first-page":"16","volume":"13","author":"Wasay M.","year":"2006","journal-title":"Int Mult Scler J"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410130302"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(200006)47:6<831::AID-ANA21>3.0.CO;2-H"},{"key":"atypb4","first-page":"16","volume":"4","author":"Raza SQ","year":"1998","journal-title":"Pakistan J Neurol"},{"key":"atypb5","first-page":"47","author":"Asif SA","year":"1999","journal-title":"CPSP Dissertations"},{"key":"atypb6","unstructured":"Olek MJ, Dawson DM Multiple sclerosis and other inflammatory demyelinating diseases ofl the central nervous system. 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Butterworth-Heinemann , 2000: 1431-66."}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458506072339","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458506072339","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:21:25Z","timestamp":1777692085000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1352458506072339"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":6,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["10.1177\/1352458506072339"],"URL":"https:\/\/doi.org\/10.1177\/1352458506072339","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,6]]}}}