{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:09:36Z","timestamp":1777936176042,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:p>Neuromyelitis optica (NMO) has been attributed to different underlying pathological events. The aim of this paper is to present the first case report of a patient with Down's syndrome (DS) who died of a fulminant NMO. A 29-year-old woman with DS developed acute transverse myelitis, with complete visual loss and swollen optic discs. Two days later, she developed quadriplegia, respiratory arrest and died. The anatomical study demonstrated typical findings of DS in the brain without demyelinating lesions. A severe destruction of medulla and cervical cord with a very high degree of demyelination of the optic nerves was typical of monophasic NMO (Devic's disease). Most of the cases of NMO in Cuba are of the relapsing form, but this case report is the first one with monophasic NMO and DS with a very aggressive course. The link of the pathogenetic relationship between DS and NMO remains unclear; it may well be coincidence but the fact that the patient died very shortly after the onset suggests, at least on clinical grounds, that the presence of DS could have accelerated the fatal evolution of NMO. Multiple Sclerosis 2007; 13: 433-436. http:\/\/msj.sagepub.com<\/jats:p>","DOI":"10.1177\/13524585070130030901","type":"journal-article","created":{"date-parts":[[2007,3,22]],"date-time":"2007-03-22T04:37:53Z","timestamp":1174538273000},"page":"433-436","source":"Crossref","is-referenced-by-count":1,"title":["Down's syndrome and neuromyelitis optica (Devic's disease). An autopsy-proven case"],"prefix":"10.1177","volume":"13","author":[{"given":"J.A.","family":"Cabrera-G\u00f3mez","sequence":"first","affiliation":[{"name":"International Center of Neurologic Restoration (CIREN), Avenida 25 15805                         entre 158 y 160, CP 11300 Reparto Cubanac\u00e1n, Playa, Ciudad de La                         Habana, Cuba,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Galarraga-Inza","sequence":"additional","affiliation":[{"name":"Laboratory of Pathologic Anatomy, National Institute of Neurology and                         Neurosurgery, 29 y D, Vedado, Havana, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.M.","family":"Coro-Antich","sequence":"additional","affiliation":[{"name":"Laboratory of Pathologic Anatomy, National Institute of Neurology and                         Neurosurgery, 29 y D, Vedado, Havana, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Real-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"International Center of Neurologic Restoration (CIREN), Avenida 25 15805                         entre 158 y 160, CP 11300 Reparto Cubanac\u00e1n, Playa, Ciudad de La                         Habana, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Cristofol-Corominas","sequence":"additional","affiliation":[{"name":"Laboratory of Pathologic Anatomy, National Institute of Neurology and                         Neurosurgery, 29 y D, Vedado, Havana, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"G\u00f3mez","sequence":"additional","affiliation":[{"name":"Laboratory of Pathologic Anatomy, National Institute of Neurology and                         Neurosurgery, 29 y D, Vedado, Havana, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Romero-Garcia","sequence":"additional","affiliation":[{"name":"International Center of Neurologic Restoration (CIREN), Avenida 25 15805                         entre 158 y 160, CP 11300 Reparto Cubanac\u00e1n, Playa, Ciudad de La                         Habana, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.X.","family":"Gil-Gil","sequence":"additional","affiliation":[{"name":"Laboratory of Pathologic Anatomy, National Institute of Neurology and                         Neurosurgery, 29 y D, Vedado, Havana, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Gonzalez-Quevedo","sequence":"additional","affiliation":[{"name":"Laboratory of Pathologic Anatomy, National Institute of Neurology and                         Neurosurgery, 29 y D, Vedado, Havana, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2007,4,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.5.1107"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-36534"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-1331.1999.640505.x"},{"key":"atypb4","first-page":"89","volume":"41","author":"Papais-Alvarenga RM","year":"2003","journal-title":"Rev Chil Neuropsiquiatr"},{"key":"atypb5","first-page":"1198","volume":"42","author":"Kira J.","year":"2002","journal-title":"Rinsho Shinkeigaku"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1097\/00019052-200306000-00002"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1177\/135245859800400503"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1159\/000047947"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.5.937"},{"key":"atypb10","unstructured":"Camacho Eiranova H                 ,                      Cobas Ruiz M                 ,                      Icart Pereira E                  eds. Por la vida: estudio psicosocial de las personas con discapacidades                     y estudio psicopedag\u00f3gico, social y                     cl\u00ednicogen\u00e9tico de las personas con retraso mental en                 Cuba.                      Casa Editora                  Abril, 2003: 127-34."}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13524585070130030901","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13524585070130030901","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:21:51Z","timestamp":1777692111000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13524585070130030901"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,4]]}},"alternative-id":["10.1177\/13524585070130030901"],"URL":"https:\/\/doi.org\/10.1177\/13524585070130030901","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,4]]}}}