{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:28:47Z","timestamp":1792510127071,"version":"4.5.0"},"reference-count":11,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T00:00:00Z","timestamp":1188604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:p>Neuromyelitis optica (NMO) is a relapsing neurologic disease characterized by severe optic neuritis and transverse myelitis. A disease-modifying therapy for NMO has not been established. We retrospectively analysed the effect of low-dose corticosteroid (CS) monotherapy on the annual relapse rate in nine patients with NMO. We divided the clinical course in each patient into two periods; the CS Period in which CS was administered, and the No CS Period in which CS was not administered. Periods related to other immunological therapies, such as high-dose methylprednisolone, immunosuppressants, interferon-beta, and plasma exchange, were excluded. As a result, the annual relapse rate during the CS Periods [median, 0.49 (range, 0\u20141.31)] was found to be significantly lower than that during the No CS Periods [1.48 (0.65\u20145.54)]. As for the dose of CS, relapses occurred significantly more frequently with `10 mg\/day or less' than with `over 10 mg\/day' (odds ratio: 8.75). The results of the present study suggest a beneficial effect of low-dose CS monotherapy in reducing relapses in NMO. Multiple Sclerosis 2007; 13: 968\u2014974. http:\/\/msj.sagepub.com<\/jats:p>","DOI":"10.1177\/1352458507077189","type":"journal-article","created":{"date-parts":[[2007,7,10]],"date-time":"2007-07-10T21:54:52Z","timestamp":1184104492000},"page":"968-974","source":"Crossref","is-referenced-by-count":151,"title":["Low-dose corticosteroids reduce relapses in neuromyelitis optica: a retrospective analysis"],"prefix":"10.1177","volume":"13","author":[{"given":"S.","family":"Watanabe","sequence":"first","affiliation":[{"name":"Department of Neurology, Tohoku University School of Medicine, Sendai, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Misu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tohoku University School of Medicine, Sendai, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Miyazawa","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tohoku University School of Medicine, Sendai, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Nakashima","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tohoku University School of Medicine, Sendai, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Shiga","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tohoku University School of Medicine, Sendai, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Fujihara","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tohoku University School of Medicine, Sendai, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Itoyama","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tohoku University School of Medicine, Sendai, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2007,9,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410340211"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.60.4.382"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.5.1107"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf260"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf151"},{"key":"atypb6","first-page":"901","volume":"53","author":"Miyazawa I.","year":"2001","journal-title":"No To Shinkei"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17551-X"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050304"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.4.1219"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20770"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000216139.44259.74"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458507077189","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458507077189","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:22:08Z","timestamp":1777692128000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1352458507077189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9]]},"references-count":11,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2007,9]]}},"alternative-id":["10.1177\/1352458507077189"],"URL":"https:\/\/doi.org\/10.1177\/1352458507077189","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,9]]}}}