{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T11:48:16Z","timestamp":1786794496139,"version":"build-2736575974"},"reference-count":26,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2007,10,17]],"date-time":"2007-10-17T00:00:00Z","timestamp":1192579200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:p>The serum uric acid (UA) levels were measured in 112 patients with multiple sclerosis (MS) and 794 patients with different types of other neurological diseases (OND) or healthy control group. Serum UA levels, along with relevant clinical parameters of MS and OND, were also investigated. MS patients had significantly lower UA levels than those with transient ischemia attack (344.6 \u00b1 130.6 \u00b5mol\/L, P = 0.000), cerebral hemorrhage (311.9 \u00b1 104.7 \u00b5mol\/L, P = 0.000), cerebral infarction (291.3 \u00b1 101.6 \u00b5mol\/L, P = 0.014) and the healthy control group (312.1 \u00b1 92.8 \u00b5mol\/L, P = 0.000). MS patients had significantly higher serum UA levels than those with cryptococcus meningitis or meningoencephalitis (178.9 \u00b1 107.0 \u00b5mol\/L, P = 0.000) and tuberculous meningitis or meningoencephalitis patients (175.7 \u00b1 99.9 \u00b5mol\/L, P = 0.000). There were no significant differences in UA levels between patients with MS and those with facial neuritis, viral meningitis or encephalitis, pulmonary tuberculosis, polymyositis or dermatomyositis, myasthenia gravis, subarachnoid hemorrhage, migraine, Guillain\u2014Barre syndrome and myelitis. In addition, UA levels were independently correlated with gender and duration of MS, but neither with MRI activity, disability nor subtypes of the disease in MS patients. Our data suggest that UA has two biphasic functions: neuroprotective and injurious. Our studies may help physicians to deal with conditions having abnormal UA levels. Multiple Sclerosis 2008; 14: 188\u2014196. http:\/\/msj.sagepub.com<\/jats:p>","DOI":"10.1177\/1352458507082143","type":"journal-article","created":{"date-parts":[[2007,10,17]],"date-time":"2007-10-17T21:04:43Z","timestamp":1192655083000},"page":"188-196","source":"Crossref","is-referenced-by-count":54,"title":["Serum uric acid levels of patients with multiple sclerosis and other neurological diseases"],"prefix":"10.1177","volume":"14","author":[{"family":"Fuhua Peng","sequence":"first","affiliation":[{"name":"Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Road, Guangzhou 510630, Guangdong Province, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Bin Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Road, Guangzhou 510630, Guangdong Province, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Xiufeng Zhong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center of Sun Yat-Sen University, 54 Xianlie Road, Guangzhou 510060, Guangdong Province, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Jin Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Road, Guangzhou 510630, Guangdong Province, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Guihong Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Road, Guangzhou 510630, Guangdong Province, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Xueqiang Hu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Road, Guangzhou 510630, Guangdong Province, People's Republic of China,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Wei Qiu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Road, Guangzhou 510630, Guangdong Province, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Zhong Pei","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Sun Yat-Sen University, 89 Zhongshaner Road, Guangzhou 510080, Guangdong Province, People's Republic of 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