{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:10:08Z","timestamp":1777936208727,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2008,1,21]],"date-time":"2008-01-21T00:00:00Z","timestamp":1200873600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:p>Ehlers\u2014Danlos syndrome (EDS) has various neurological manifestations. Here we present an association of EDS with multiple sclerosis (MS). Four MS patients from a total of 1892 followed up at our MS outpatient clinics had EDS. This frequency suggests 10\u201411 times increased prevalence of EDS in MS patients compared with the general population ( P = 0.02). Suggested implications include a possible causal relationship on a connective tissue level with a higher susceptibility to MS in EDS. Diagnostic and management considerations are important in coexisting MS and EDS. Our patients had relatively florid lesions on brain MRIs and typical course and features of MS. Multiple Sclerosis 2008; 14 : 567\u2014570. http:\/\/msj.sagepub.com<\/jats:p>","DOI":"10.1177\/1352458507083187","type":"journal-article","created":{"date-parts":[[2008,1,21]],"date-time":"2008-01-21T20:33:38Z","timestamp":1200947618000},"page":"567-570","source":"Crossref","is-referenced-by-count":10,"title":["Ehlers\u2014Danlos syndrome and multiple sclerosis: a possible                 association"],"prefix":"10.1177","volume":"14","author":[{"given":"J.","family":"Vilisaar","sequence":"first","affiliation":[{"name":"Division of Clinical Neurology, Faculty of Medicine and Health Sciences,                         University of Nottingham, Queen's Medical Centre, Nottingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Harikrishnan","sequence":"additional","affiliation":[{"name":"Division of Clinical Neurology, Faculty of Medicine and Health Sciences,                         University of Nottingham, Queen's Medical Centre, Nottingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Suri","sequence":"additional","affiliation":[{"name":"Clinical Genetics Service, City Hospital, Nottingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CS","family":"Constantinescu","sequence":"additional","affiliation":[{"name":"Division of Clinical Neurology, Faculty of Medicine and Health Sciences,                         University of Nottingham, Queen's Medical Centre, Nottingham, UK,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2008,1,21]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19980428)77:1<31::AID-AJMG8>3.0.CO;2-O"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1999.tb00742.x"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.57.1.123"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19961211)66:2<239::AID-AJMG23>3.0.CO;2-T"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.33.8.1087"},{"key":"atypb6","unstructured":"Steinmann B.                 ,                      Royce PM                 ,                      Superti-Furga A. The Ehlers-Danlos syndrome. In                      Royce PM                  ,                      Steinmann B                 , eds. Connective Tissue and its Heritable Disorders.                         New York :                 Wiley-Liss, 1993:                 351-408."},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1191\/1352458504ms1087oa"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2001000500007"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2990.1999.00176.x"},{"key":"atypb10","volume-title":"Annual Meeting of the American Society of Human Genetics","author":"Gustafson A."}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458507083187","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458507083187","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:22:59Z","timestamp":1777692179000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1352458507083187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1,21]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["10.1177\/1352458507083187"],"URL":"https:\/\/doi.org\/10.1177\/1352458507083187","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1,21]]}}}