{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T18:18:35Z","timestamp":1790965115698,"version":"4.1.0"},"reference-count":19,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2008,1,21]],"date-time":"2008-01-21T00:00:00Z","timestamp":1200873600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:p>Background A serum autoantibody biomarker, NMO-IgG has been recently described in patients with Devic's neuromyelitis optica (DNMO) and so called `high-risk' patients for this disease. Our objectives were to replicate the test and to assess its usefulness.<\/jats:p>\n                  <jats:p>Methods Indirect immunofluorescence with a substrate of adult rat cerebellum and midbrain was used to identify the distinctive NMO-IgG staining pattern. We tested masked sera from 26 patients with DNMO (group 1), 21 patients with idiopathic acute transverse myelitis (ATM) (group 2), 21 patients with bilateral and\/or recurrent idiopathic optic neuritis (group 3), 52 patients with classical multiple sclerosis (MS) (group 4), 36 patients with HTLV-1 infection (group 5) and 7 patients with miscellaneous disorders (group 6).<\/jats:p>\n                  <jats:p>Results We identified a vascular staining pattern typical of NMO-IgG. This particular staining was observed in 14\/26 samples in group 1, 7\/21 in group 2 (positive only in longitudinally extensive acute transverse myelitis: 7\/13), 4\/21 in group 3 (with bilateral loss of vision in all seropositive cases), 5\/52 in group 4 (none of them suggestive of DNMO), 0\/36 in group 5 and 0\/7 in group 6. Sensitivity of the test was 54% considering detection of DNMO (group 1), and specificity was respectively 94% and 90% when considering groups 4, 5 and 6 altogether or group 4 of MS patients only.<\/jats:p>\n                  <jats:p>Conclusion Detection of NMO-IgG is contributory to the distinction of DNMO and `DNMO high-risk' syndromes from MS. This test may allow earlier diagnosis and help therapeutic decisions. Multiple Sclerosis 2008; 14: 440\u2014445. http:\/\/msj.sagepub.com<\/jats:p>","DOI":"10.1177\/1352458507084595","type":"journal-article","created":{"date-parts":[[2008,1,21]],"date-time":"2008-01-21T20:33:38Z","timestamp":1200947618000},"page":"440-445","source":"Crossref","is-referenced-by-count":91,"title":["NMO-IgG and Devic's neuromyelitis optica: a French experience"],"prefix":"10.1177","volume":"14","author":[{"given":"Romain","family":"Marignier","sequence":"first","affiliation":[{"name":"Service de Neurologie A and EDMUS Co-ordinating Center,                         H\u00f4pital Neurologique Pierre Wertheimer, Hospices Civils de Lyon,                         59 boulevard Pinel Lyon Bron cedex, F-69677, France, Inserm U 842, Lyon, F-69008,                         France, Universit\u00e9 de Lyon, Lyon, F-69003; Universit\u00e9                         Lyon 1, Lyon, F-69003, France,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"De S\u00e8ze","sequence":"additional","affiliation":[{"name":"H\u00f4pital Civil de Strasbourg, Strasbourg, F-67000,                     France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Vukusic","sequence":"additional","affiliation":[{"name":"Service de Neurologie A and EDMUS Co-ordinating Center,                         H\u00f4pital Neurologique Pierre Wertheimer, Hospices Civils de Lyon,                         59 boulevard Pinel Lyon Bron cedex, F-69677, France, Inserm U 842, Lyon,                         F-69008, France, Universit\u00e9 de Lyon, Lyon, F-69003;                         Universit\u00e9 Lyon 1, Lyon, F-69003, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Durand-Dubief","sequence":"additional","affiliation":[{"name":"Service de Neurologie A and EDMUS Co-ordinating Center,                         H\u00f4pital Neurologique Pierre Wertheimer, Hospices Civils de Lyon,                         59 boulevard Pinel Lyon Bron cedex, F-69677, France, Universit\u00e9                         de Lyon, Lyon, F-69003; Universit\u00e9 Lyon 1, Lyon, F-69003,                     France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Z\u00e9phir","sequence":"additional","affiliation":[{"name":"CHRU de Lille, Lille, F-59000, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Vermersch","sequence":"additional","affiliation":[{"name":"CHRU de Lille, Lille, F-59000, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Cabre","sequence":"additional","affiliation":[{"name":"CHU Fort de France, F-97200, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u00eblle","family":"Cavillon","sequence":"additional","affiliation":[{"name":"Inserm U 842, Lyon, F-69008, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Honnorat","sequence":"additional","affiliation":[{"name":"Inserm U 842, Lyon, F-69008, France, Universit\u00e9 de Lyon, Lyon,                         F-69003; Universit\u00e9 Lyon 1, Lyon, F-69003, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Confavreux","sequence":"additional","affiliation":[{"name":"Service de Neurologie A and EDMUS Co-ordinating Center,                         H\u00f4pital Neurologique Pierre Wertheimer, Hospices Civils de Lyon,                         59 boulevard Pinel Lyon Bron cedex, F-69677, France, Inserm U 842, Lyon,                         F-69008, France, Universit\u00e9 de Lyon, Lyon, F-69003;                         Universit\u00e9 Lyon 1, Lyon, F-69003, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2008,1,21]]},"reference":[{"key":"atypb1","first-page":"1033","volume":"8","author":"Devic E.","year":"1894","journal-title":"Bull Med"},{"key":"atypb2","author":"Gault F.","year":"1894","journal-title":"Facult\u00e9 de M\u00e9decine et de Pharmacie de Lyon"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.5.1107"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1191\/1352458503ms947oa"},{"key":"atypb5","first-page":"180","volume":"6","author":"Jacob A.","year":"2006","journal-title":"J Neurol Neurosurg Psychiatry (compl)"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf151"},{"key":"atypb7","first-page":"42","volume":"13","author":"Wingerchuk DM","year":"2006","journal-title":"Int MS J"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-36534"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17551-X"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm062"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneuro0420"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1002\/ana.1032"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.2.244"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.4.907"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200011163432001"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000256822.01222.bd"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000216139.44259.74"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.1.250"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20770"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458507084595","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458507084595","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:23:15Z","timestamp":1777692195000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1352458507084595"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1,21]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["10.1177\/1352458507084595"],"URL":"https:\/\/doi.org\/10.1177\/1352458507084595","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1,21]]}}}