{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:07:38Z","timestamp":1793210858211,"version":"4.5.0"},"reference-count":52,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:p>Background<\/jats:p>\n                  <jats:p>Multiple sclerosis (MS) and other autoimmune diseases might cluster. Our aim was to estimate the relative risk (RR) of other autoimmune diseases among MS patients and their first-degree relatives in a population-based cohort study.<\/jats:p>\n                  <jats:p>Methods<\/jats:p>\n                  <jats:p>Using the Danish Multiple Sclerosis Register, the Danish Hospital Discharge Register, and the Danish Civil Registration System, we estimated RRs for 42 different autoimmune diseases in a population-based cohort of 12 403 MS patients and 20 798 of their first-degree relatives. Ratios of observed to expected numbers of autoimmune diseases, based on national sex-, age-, and period-specific incidence rates, served as measures of the RRs.<\/jats:p>\n                  <jats:p>Results<\/jats:p>\n                  <jats:p>Compared with the general population, MS patients were at an increased risk of developing ulcerative colitis (RR\u2004=\u20042.0 (95% confidence interval (CI): 1.4\u20132.8), n\u2004=\u200429) and pemphigoid (RR\u2004=\u200415.4 (CI: 8.7\u201327.1), n\u2004=\u200412) but at reduced risk of rheumatoid arthritis (RR\u2004=\u20040.5 (CI: 0.4\u20130.8), n\u2004=\u200428) and temporal arteritis (RR\u2004=\u20040.5 (CI: 0.3\u20130.97), n\u2004=\u200411). First-degree relatives of MS patients were at increased risks of Crohn\u2019s disease (RR\u2004=\u20041.4 (CI: 1.04\u20131.9), n\u2004=\u200444), ulcerative colitis (RR\u2004=\u20041.3 (CI: 0.99\u20131.7), n\u2004=\u200451), Addison\u2019s disease (RR\u2004=\u20043.4 (CI: 1.3\u20139.0), n\u2004=\u20044), and polyarteritis nodosa (RR\u2004=\u20043.7 (CI: 1.4\u201310.0), n\u2004=\u20044).<\/jats:p>\n                  <jats:p>Conclusion<\/jats:p>\n                  <jats:p>Patients with MS and their first-degree relatives seem to be at an increased risk of acquiring certain other autoimmune diseases.<\/jats:p>","DOI":"10.1177\/1352458508088936","type":"journal-article","created":{"date-parts":[[2008,6,23]],"date-time":"2008-06-23T20:35:46Z","timestamp":1214253346000},"page":"823-829","source":"Crossref","is-referenced-by-count":107,"title":["Autoimmune diseases in patients with multiple sclerosis and their                 first-degree relatives: a nationwide cohort study in Denmark"],"prefix":"10.1177","volume":"14","author":[{"given":"NM","family":"Nielsen","sequence":"first","affiliation":[{"name":"Department of Epidemiology Research, Statens Serum Institut, Copenhagen,                         Denmark,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Frisch","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Research, Statens Serum Institut, Copenhagen,                         Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Rostgaard","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Research, Statens Serum Institut, Copenhagen,                         Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Wohlfahrt","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Research, Statens Serum Institut, Copenhagen,                         Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Hjalgrim","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Research, Statens Serum Institut, Copenhagen,                         Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Koch-Henriksen","sequence":"additional","affiliation":[{"name":"The Danish Register of Multiple Sclerosis, National University Hospital,                         Copenhagen, Denmark; Department of Neurology, Aarhus University Hospital in                         Aalborg, Aalborg, Denmark; National Institute of Public Health, Copenhagen,                         Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Melbye","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Research, Statens Serum Institut, Copenhagen,                         Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Westergaard","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Research, Statens Serum Institut, Copenhagen,                         Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2008,7,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1177\/135245859900500209"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1177\/135245859800400322"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200009283431307"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1006\/jaut.2002.0588"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.33.1.97"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.1972.tb03071.x"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(06)70552-X"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.4.883"},{"key":"atypb9","first-page":"1584","volume":"84","author":"Noseworthy JH","year":"1989","journal-title":"Am J Gastroenterol"},{"key":"atypb10","first-page":"415","volume":"84","author":"Taub WH","year":"1989","journal-title":"Am J Gastroenterol"},{"key":"atypb11","first-page":"173","volume":"99","author":"Shepherd DI","year":"1974","journal-title":"Trans Am Neurol Assoc"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1998.tb01733.x"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1159\/000249506"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780290116"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.26.6.544"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(83)90032-2"},{"key":"atypb17","doi-asserted-by":"crossref","unstructured":"17 Eaton WW; Rose NR; Kalaydjian A; Pedersen MG; Mortensen PB; Epidemiology                 of autoimmune diseases in Denmark. 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