{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:19:30Z","timestamp":1790651970398,"version":"4.1.0"},"reference-count":23,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:p>Devic\u2019s disease is often considered as a variant of multiple sclerosis (MS). However, evidence suggests that Devic\u2019s disease may be distinct from MS. Devic\u2019s disease can coexist with connective tissue diseases, particularly Sj\u00f6gren\u2019s disease, but this association is rare with MS. Diagnosis of Sj\u00f6gren\u2019s disease in patients with neurological symptoms is often difficult. During early stages of Sj\u00f6gren\u2019s disease, patients may not fulfill all criteria for Sj\u00f6gren\u2019s disease. A high percentage of patients with Sj\u00f6gren\u2019s disease have inflammatory infiltrates in minor salivary glands, and this may be a reliable indicator of early or subclinical disease. We show high prevalence (80%) of salivary gland inflammation in Devic\u2019s disease and longitudinally extensive transverse myelitis (LETM). We diagnosed 16 patients with Devic\u2019s disease, and 2 of these satisfied criteria for Sj\u00f6gren\u2019s disease as did 2 of 9 patients with LETM. Anti-SSA\/B titers were infrequently elevated. Although most did not satisfy criteria for Sj\u00f6gren\u2019s disease. 9 of 12 Devic\u2019s disease patients and 7 of 8 LETM patients had severe salivary gland inflammation. Thus: (1) patients with Devic\u2019s disease or with LETM who have positive labial biopsies but do not satisfy criteria for Sj\u00f6gren\u2019s disease could have subclinical Sj\u00f6gren\u2019s diseases. Alternatively, (2) as patients with Devic\u2019s disease have elevated titers of several autoantibodies, so there may exist a set of antibodies that react with antigens in minor salivary glands and cause inflammation. Minor salivary gland biopsy is more sensitive than anti-SSA\/B serology in providing histological evidence for possible Sj\u00f6gren\u2019s disease with CNS lesions.<\/jats:p>","DOI":"10.1177\/1352458508088941","type":"journal-article","created":{"date-parts":[[2008,6,23]],"date-time":"2008-06-23T20:35:46Z","timestamp":1214253346000},"page":"809-814","source":"Crossref","is-referenced-by-count":55,"title":["Minor salivary gland inflammation in Devic\u2019s disease and                 longitudinally extensive myelitis"],"prefix":"10.1177","volume":"14","author":[{"given":"A","family":"Javed","sequence":"first","affiliation":[{"name":"Department of Neurology, University of Chicago, Chicago, IL, USA,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Balabanov","sequence":"additional","affiliation":[{"name":"Department of Neurology, Rush University Medical Center, Chicago,                         Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BGW","family":"Arnason","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Chicago, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TJ","family":"Kelly","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Chicago, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NJ","family":"Sweiss","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, University of Chicago, Chicago, IL,                     USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Pytel","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Chicago, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Walsh","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Chicago, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EA","family":"Blair","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\/Head and Neck Surgery, University of                         Chicago, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Stemer","sequence":"additional","affiliation":[{"name":"Department of Neurology, Rush University Medical Center, Chicago,                         Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Lazzaro","sequence":"additional","affiliation":[{"name":"Department of Neurology, Rush University Medical Center, Chicago,                         Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AT","family":"Reder","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Chicago, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2008,7,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000216139.44259.74"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.3.390"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-004-0271-0"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20770"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(02)00043-6"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.5.1107"},{"key":"atypb7","unstructured":"7 Weinshenker B; Pittock S; de Seze J; Vermersch P; Wingerchuk D; Zephir JH; The relationship between neuromyelitis optica and systemic autoimmune disease.                 Mult Scler 2006; 12: 79, S16."},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1136\/ard.61.6.554"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1136\/ard.55.2.116"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1097\/01.md.0000141099.53742.16"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/120.11.2059"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.21.5.656"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410340211"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.60.4.382"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1991.tb04906.x"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.8.1359"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1191\/1352458503ms905oa"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17551-X"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000049912.02954.2C"},{"key":"atypb20","unstructured":"20 Pittock SJ; Weinshenker BG; Wingerchuk DM; Lucchinetti CF; Lennon VA;                 Autoimmune neurological accompaniments of neuromyelitis optica (NMO). Ann Neurol                 2006; 60 (Suppl 10): S41, M-24."},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.7.964"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2006.01.022"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/25.17.3389"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458508088941","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458508088941","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:23:51Z","timestamp":1777692231000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1352458508088941"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["10.1177\/1352458508088941"],"URL":"https:\/\/doi.org\/10.1177\/1352458508088941","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,7]]}}}