{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:10:54Z","timestamp":1777936254713,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2008,7,16]],"date-time":"2008-07-16T00:00:00Z","timestamp":1216166400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:p>Diagnosis of primary angiitis of the central nervous system (PACNS) is difficult in relation to variability in its clinical manifestations and absence of specific signs in neuroimaging. A young patient presented with a recurrent encephalopathic clinical course. T2 and fluid-attenuated inversion recovery-magnetic resonance imaging (FLAIR-MRI) showed hyperintense lesions in the cerebral white matter suggesting demyelination. Those lesions decreased or even disappeared after treatment with steroids and immunoglobulins. In echo gradient MRI (T2*-MRI), there were permanent cortical-subcortical petechial hypointense lesions (microhemorrhages). Definite diagnosis was established after cerebral biopsy. Intravenous cyclophosphamide was administrated with no new relapses in more than 18\u00a0months of follow-up. In a compatible clinical course, the finding of petechial hemorrhages in T2*-WI could play an important role in early diagnosis of PACNS.<\/jats:p>","DOI":"10.1177\/1352458508094642","type":"journal-article","created":{"date-parts":[[2008,8,26]],"date-time":"2008-08-26T06:33:15Z","timestamp":1219732395000},"page":"1139-1141","source":"Crossref","is-referenced-by-count":12,"title":["Recurrent leukoencephalopathy with microhemorrhages: gradient-echo MRI study diagnostic value in CNS primary angiitis"],"prefix":"10.1177","volume":"14","author":[{"given":"M","family":"Arias","sequence":"first","affiliation":[{"name":"Department of Neurology, Complexo Hospitalario, Universitario, Santiago de Compostela, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XR","family":"Osorio","sequence":"additional","affiliation":[{"name":"Department of Neurology, Complexo Hospitalario, Universitario, Santiago de Compostela, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Dapena","sequence":"additional","affiliation":[{"name":"Department of Neurology, Complexo Hospitalario, Universitario, Santiago de Compostela, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Arias-Rivas","sequence":"additional","affiliation":[{"name":"Department of Neurology, Complexo Hospitalario, Universitario, Santiago de Compostela, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Department of Radiology, Complexo Hospitalario, Universitario, Santiago de Compostela, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2008,7,16]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198801000-00002"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1007\/s004150050285"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1159\/000052120"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hci098"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1177\/014107680009301108"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1993.00540090032007"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410370713"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1046\/j.0004-8461.2003.01140.x"},{"key":"atypb9","first-page":"1561","volume":"23","author":"Ay H","year":"2002","journal-title":"AJNR Am J Neuroradiol"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1097\/00019052-200406000-00014"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458508094642","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458508094642","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:24:25Z","timestamp":1777692265000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1352458508094642"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7,16]]},"references-count":10,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2008,9]]}},"alternative-id":["10.1177\/1352458508094642"],"URL":"https:\/\/doi.org\/10.1177\/1352458508094642","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,7,16]]}}}