{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:10:55Z","timestamp":1777936255483,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2008,10,9]],"date-time":"2008-10-09T00:00:00Z","timestamp":1223510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:p>Introduction<\/jats:p>\n                  <jats:p>The association of neuromyelitis optica (NMO) and multiple sclerosis (MS) has been reported, but details of the cases were not described. We report two Venezuelan Caucasian sisters with human leukocyte antigen (HLA) typing.<\/jats:p>\n                  <jats:p>Results<\/jats:p>\n                  <jats:p>Patient 1 fulfilled McDonald, et\u00a0al. criteria with HLA A*24; B*07,*15; DRB1*01,*16 (DR2 positive). Patient 2 fulfilled the NMO revised criteria of Wingerchuck, et\u00a0al. with HLA A*02,*24; B*07,*40; DRB1*04,*08, similar to Canadian aboriginal NMO cases and the Yukpa population from Venezuela.<\/jats:p>\n                  <jats:p>Conclusion<\/jats:p>\n                  <jats:p>These cases confirmed the coexistence of NMO and MS in sisters, and further studies are needed to understand the genetic linkage between these diseases.<\/jats:p>","DOI":"10.1177\/1352458508097921","type":"journal-article","created":{"date-parts":[[2008,10,15]],"date-time":"2008-10-15T23:13:52Z","timestamp":1224112432000},"page":"269-271","source":"Crossref","is-referenced-by-count":14,"title":["Neuromyelitis optica and multiple sclerosis in sisters"],"prefix":"10.1177","volume":"15","author":[{"given":"JA","family":"Cabrera-G\u00f3mez","sequence":"first","affiliation":[{"name":"Multiple Sclerosis Society and Multiple Sclerosis Clinic, International Center of Neurological Restoration, Havana, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Ram\u00f3n-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Neurological Service and Direction Department, Health International Center, La Pradera"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Saiz","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Neurology and Immunology, Hospital Cl\u00ednic Barcelona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Llerena-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Neurological Service and Direction Department, Health International Center, La Pradera"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Fern\u00e1ndez-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Neurological Service and Direction Department, Health International Center, La Pradera"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Ercilla","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Neurology and Immunology, Hospital Cl\u00ednic Barcelona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Grass-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Society and Multiple Sclerosis Clinic, International Center of Neurological Restoration, Havana, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MA","family":"Robinson-Agramonte","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Society and Multiple Sclerosis Clinic, International Center of Neurological Restoration, Havana, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Romero-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Society and Multiple Sclerosis Clinic, International Center of Neurological Restoration, Havana, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Mac\u00edas-Betancourt","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Society and Multiple Sclerosis Clinic, International Center of Neurological Restoration, Havana, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Galvizu-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Society and Multiple Sclerosis Clinic, International Center of Neurological Restoration, Havana, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Otero-Motol\u00e1","sequence":"additional","affiliation":[{"name":"Neurological Service and Direction Department, Health International Center, La Pradera"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Sojo-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Society and Multiple Sclerosis Clinic, International Center of Neurological Restoration, Havana, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Aguilar-Arias","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Society and Multiple Sclerosis Clinic, International Center of Neurological Restoration, Havana, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Rodr\u00edguez-Cordero","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Society and Multiple Sclerosis Clinic, International Center of Neurological Restoration, Havana, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Gonz\u00e1lez-Quevedo","sequence":"additional","affiliation":[{"name":"Biochemistry Department , Institute of Neurology and Neurosurgery, Havana, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2008,10,9]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000216139.44259.74"},{"key":"atypb2","doi-asserted-by":"crossref","first-page":"A-266","DOI":"10.1212\/01.wnl.0000303817.82134.da","volume":"70","author":"Matiello M","year":"2008","journal-title":"Neurology"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.5.937"},{"key":"atypb4","doi-asserted-by":"crossref","unstructured":"4 Cabrera-G\u00f3mez JA; \u2004Kurtzke JF; \u2004Gonz\u00e1lez-Quevedo A; \u2004Lara-Rodriguez R; \u2004. An epidemiological study of neuromyelitis optica in Cuba. J Neurol 2008 ID jneuro [in press].","DOI":"10.1007\/s00415-009-0009-0"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.3.317"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/120.11.2059"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1177\/1352458506070725"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1002\/ana.1032"},{"key":"atypb9","unstructured":"9 Matsouka T; \u2004Matsushita T; \u2004Osoegawa M; \u2004. Association of the HLA-DRB1 alleles with characteristics MRI features of Asian multiple sclerosis.\n                      Mult Scler\n                      [in press]."},{"key":"atypb10","first-page":"A266","volume":"70","author":"Zephyr H","year":"2008","journal-title":"Neurology"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458508097921","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458508097921","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:24:57Z","timestamp":1777692297000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1352458508097921"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10,9]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["10.1177\/1352458508097921"],"URL":"https:\/\/doi.org\/10.1177\/1352458508097921","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10,9]]}}}