{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:11:05Z","timestamp":1777936265275,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2009,1,19]],"date-time":"2009-01-19T00:00:00Z","timestamp":1232323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:p>Objective<\/jats:p>\n                  <jats:p>Because Asian patients with opticospinal multiple sclerosis (OSMS) frequently have anti-aquaporin-4 (AQP4) antibody, complement-mediated disruption of astrocyte foot processes is proposed but not yet proven. We aimed to clarify whether complement consumption occurs at relapse in anti-AQP4 antibody-positive patients.<\/jats:p>\n                  <jats:p>Methods<\/jats:p>\n                  <jats:p>\n                    We analyzed serum CH50, C3, C4, and C-reactive protein (CRP) levels and their relation to clinical phases in 118 MS patients with or without anti-AQP4 antibody. Serum CH50 levels were higher in 24 patients with anti-AQP4 antibody than in 39 OSMS and 54 conventional form of MS (CMS) patients without anti-AQP4 antibody at relapse ( P\n                    <jats:sup>corr<\/jats:sup>\n                    \u00a0&lt;\u00a00.05) but not in remission. The frequency of hypercomplementemia at relapse was also higher in anti-AQP4 antibody-positive patients than in anti-AQP4 antibody-negative CMS patients (70.4% vs 29.0%, P\n                    <jats:sup>corr<\/jats:sup>\n                    \u00a0&lt;\u00a00.05). C3 and C4 levels did not differ significantly among the three groups at relapse. In patients with anti-AQP4 antibody, the coexistence of hypercomplementemia and high CRP values was more common at relapse than in the remission phase (36.0% vs 10.5%, P\u00a0&lt;\u00a00.05). In patients with extensive central nervous system lesions, hypercomplementemia was significantly more common in anti-AQP4 antibody-positive patients than anti-AQP4 antibody-negative ones (88.9% vs 16.7%, P\u00a0&lt;\u00a00.01). We consider that hypercomplementemia in anti-AQP4 antibody-positive patients may reflect a systemic inflammatory reaction at relapse.\n                  <\/jats:p>","DOI":"10.1177\/1352458508099139","type":"journal-article","created":{"date-parts":[[2008,11,21]],"date-time":"2008-11-21T21:06:40Z","timestamp":1227301600000},"page":"304-310","source":"Crossref","is-referenced-by-count":29,"title":["Hypercomplementemia at relapse in patients with anti-aquaporin-4 antibody"],"prefix":"10.1177","volume":"15","author":[{"given":"H","family":"Doi","sequence":"first","affiliation":[{"name":"Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Matsushita","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Isobe","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Matsuoka","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Minohara","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Ochi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JI","family":"Kira","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,1,19]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1507"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.5.1107"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000216139.44259.74"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17551-X"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050304"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(03)00308-9"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410400405"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-36534"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf151"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/122.9.1689"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh453"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2005.080390"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm062"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl371"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm047"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000289761.64862.ce"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2007.04.009"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1191\/0961203304lu1080oa"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh407"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(88)80087-1"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kem079"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.3.390"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm027"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410130302"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.33.11.1444"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(90)90036-M"},{"key":"atypb27","doi-asserted-by":"publisher","DOI":"10.1177\/1352458507084085"},{"key":"atypb28","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200104053441406"},{"key":"atypb29","first-page":"291","volume":"59","author":"Lin 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