{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T22:52:22Z","timestamp":1779144742477,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2009,4,21]],"date-time":"2009-04-21T00:00:00Z","timestamp":1240272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:p>Background<\/jats:p>\n                  <jats:p>Vitamin D is important for bone health and immune regulation, and has been shown to be low in multiple sclerosis (MS). We sought to determine the effect of over the counter low dose cholecalciferol (LDC) and high dose ergocalciferol (HDE) on the vitamin D levels in MS patients.<\/jats:p>\n                  <jats:p>Methods<\/jats:p>\n                  <jats:p>We retrospectively evaluated serum 25-hydroxy-vitamin D [25(OH)D] levels of 199 patients (CIS, n\u00a0=\u00a032; RRMS, n\u00a0=\u00a0115; PPMS, n\u00a0=\u00a010; SPMS, n\u00a0=\u00a016; Transverse Myelitis (TM), n\u00a0=\u00a09; other neurological diseases, n\u00a0=\u00a016) attending our clinic between 2004 and 2008. We examined the change in 25(OH)D levels in 40\u00a0MS patients who took either LDC (\u2264800\u00a0IU\/day) or HDE (50,000 IU\/day for 7-10 days, followed by 50,000\u00a0IU weekly or biweekly).<\/jats:p>\n                  <jats:p>Results<\/jats:p>\n                  <jats:p>The average 25(OH)D level was 71\u00a0\u00b1\u00a039\u00a0nmol\/L (Mean\u00a0\u00b1\u00a0SD), and 167(84%) patients had insufficient levels (\u2264100\u00a0nmol\/L) of 25(OH)D. The patients supplemented with LDC did not have a significant increase in their 25(OH)D levels. However, 25(OH)D levels increased by 42\u00a0nmol\/L ( P\u00a0=\u00a00.01) in the patients originally taking LDC and then prescribed HDE. Optimal levels (\u2265100\u00a0nmol\/L) were only achieved in less than 40% of patients.<\/jats:p>\n                  <jats:p>Conclusions<\/jats:p>\n                  <jats:p>We conclude that large numbers of patients with MS and TM in our cohort are deficient in vitamin D. HDE significantly elevated 25(OH)D levels in MS patients and was more effective at increasing 25(OH)D levels than LDC. Prospective studies are required to determine appropriate dosing regimen to achieve optimal levels in the majority of MS patients and to ascertain the safety, immunological response, and ultimately the clinical efficacy of vitamin D replacement therapy.<\/jats:p>","DOI":"10.1177\/1352458509102844","type":"journal-article","created":{"date-parts":[[2009,4,21]],"date-time":"2009-04-21T22:08:34Z","timestamp":1240351714000},"page":"735-740","source":"Crossref","is-referenced-by-count":56,"title":["Vitamin D status and effect of low-dose cholecalciferol and high-dose ergocalciferol supplementation in multiple sclerosis"],"prefix":"10.1177","volume":"15","author":[{"given":"GS","family":"Hiremath","sequence":"first","affiliation":[{"name":"Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Cettomai","sequence":"additional","affiliation":[{"name":"Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Baynes","sequence":"additional","affiliation":[{"name":"Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JN","family":"Ratchford","sequence":"additional","affiliation":[{"name":"Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Newsome","sequence":"additional","affiliation":[{"name":"Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Harrison","sequence":"additional","affiliation":[{"name":"Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Kerr","sequence":"additional","affiliation":[{"name":"Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BM","family":"Greenberg","sequence":"additional","affiliation":[{"name":"Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PA","family":"Calabresi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,4,21]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.4.1161"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20061775"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.069831"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.1.270"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2005.04.013"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.4.2061"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M011033200"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.2001.6221"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1038\/ni1549"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.23.2832"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000101723.79681.38"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1016\/0306-9877(86)90010-1"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2004.056499"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20703"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.59.4.499"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra070553"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/135.11.2739S"},{"key":"atypb18","unstructured":"18 Zadshir A; \u2004Tareen N; \u2004Pan D; \u2004Norris K; \u2004Martins D; \u2004. The prevalence of hypovitaminosis D among us adults: data from the NHANES III.\n                      Ethn Dis\n                      2005;\n                      15\n                      : S5\u201397\u2013101."},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2006.12.017"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.9.1687"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-2308"},{"key":"atypb22","unstructured":"22 Jodie MB; \u2004Samantha K; \u2004Reinhold V; \u2004. Phase I\/II Dose Escalation Trial of Oral Vitamin D3 with Calcium Supplementation in Patients with Multiple Sclerosis. American Academy of Neurology 2008; 70(Suppl. 1): 105."},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/86.3.645"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/135.2.317"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2004.03.038"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.070690"},{"key":"atypb27","doi-asserted-by":"publisher","DOI":"10.1038\/nm1651"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458509102844","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458509102844","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:25:50Z","timestamp":1777692350000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1352458509102844"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4,21]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["10.1177\/1352458509102844"],"URL":"https:\/\/doi.org\/10.1177\/1352458509102844","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,4,21]]}}}