{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T04:47:22Z","timestamp":1782449242993,"version":"3.54.5"},"reference-count":28,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2009,5,22]],"date-time":"2009-05-22T00:00:00Z","timestamp":1242950400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2009,7]]},"abstract":"<jats:p>Purpose<\/jats:p>\n                  <jats:p>To evaluate retinal nerve fiber layer thickness (RNFLT) using optical coherence tomography (OCT) in children with acquired demyelinating diseases.<\/jats:p>\n                  <jats:p>Methods<\/jats:p>\n                  <jats:p>This is a cross-sectional study of patients seen between 2006\u20132008 at the Pediatric MS Center of the Jacobs Neurological Institute. Consensus definitions for pediatric demyelinating disease were followed. All children received OCT testing and assessment of visual acuity (VA) using Snellen and low contrast letter acuity (LCLA) charts.<\/jats:p>\n                  <jats:p>Results<\/jats:p>\n                  <jats:p>Thirty-eight children diagnosed with acquired demyelinating disease, 15 healthy controls, and five children with other neurological disorders (OND) were included. Average RNFLT in healthy controls was 107\u00a0\u00b1\u00a012\u00a0\u03bcm( n\u00a0=\u00a030) versus 108\u00a0\u00b1\u00a05\u00a0\u03bcm ( n\u00a0=\u00a010) in OND controls. In children with multiple sclerosis, average RNFLT\u00a0\u00b1\u00a0SD was 99\u00a0\u00b1\u00a014\u00a0\u03bcm in unaffected ( n\u00a0=\u00a024) versus 83\u00a0\u00b1\u00a012\u00a0\u03bcmin eyes affected by optic neuritis (\u201caffected eyes\u201d) ( n\u00a0=\u00a010). Average RNFLT in children with acute disseminated encephalomyelitis and transverse myelitis was 102\u00a0\u00b1\u00a015\u00a0\u03bcm in unaffected ( n\u00a0=\u00a018) versus 67\u00a0\u00b1\u00a017\u00a0\u03bcm in affected eyes ( n\u00a0=\u00a06). In children with optic neuritis (ON), average RNFLT\u00a0\u00b1\u00a0SD was 97\u00a0\u00b1\u00a013\u00a0\u03bcm in unaffected ( n\u00a0=\u00a05) versus 89\u00a0\u00b1\u00a012\u00a0\u03bcm in affected eyes ( n\u00a0=\u00a09). Differences between children with demyelinating disease and controls and between ON and nonON eyes were statistically significant ( P\u00a0&lt;\u00a00.001). Bivariate correlations of RNFLT with LCLA ( P\u00a0=\u00a00.002) and VA ( P\u00a0&lt;\u00a00.001) were significant.<\/jats:p>\n                  <jats:p>Conclusions<\/jats:p>\n                  <jats:p>OCT may be a valuable tool for the assessment and monitoring of anterior optic pathway dysfunction in children with demyelinating diseases.<\/jats:p>","DOI":"10.1177\/1352458509104586","type":"journal-article","created":{"date-parts":[[2009,5,22]],"date-time":"2009-05-22T20:36:22Z","timestamp":1243024582000},"page":"802-810","source":"Crossref","is-referenced-by-count":57,"title":["Retinal nerve fiber thickness in inflammatory demyelinating diseases of childhood onset"],"prefix":"10.1177","volume":"15","author":[{"given":"EA","family":"Yeh","sequence":"first","affiliation":[{"name":"Pediatric Multiple Sclerosis Center, State University of New York at Buffalo, Buffalo, New York, USA; Departments of Neurology, State University of New York at Buffalo, Buffalo, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Weinstock-Guttman","sequence":"additional","affiliation":[{"name":"Pediatric Multiple Sclerosis Center, State University of New York at Buffalo, Buffalo, New York, USA; Departments of Neurology, State University of New York at Buffalo, Buffalo, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Lincoff","sequence":"additional","affiliation":[{"name":"Ross Eye Institute, State University of New York at Buffalo, Buffalo, New York, USA; Ophthalmology, State University of New York at Buffalo, Buffalo, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Ross Eye Institute, State University of New York at Buffalo, Buffalo, New York, USA; Ophthalmology, State University of New York at Buffalo, Buffalo, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Weinstock","sequence":"additional","affiliation":[{"name":"Departments of Neurology, State University of New York at Buffalo, Buffalo, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Madurai","sequence":"additional","affiliation":[{"name":"Pediatric Multiple Sclerosis Center, State University of New York at Buffalo, Buffalo, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Pediatric Multiple Sclerosis Center, State University of New York at Buffalo, Buffalo, New York, USA; Departments of Neurology, State University of New York at Buffalo, Buffalo, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Buch","sequence":"additional","affiliation":[{"name":"Ross Eye Institute, State University of New York at Buffalo, Buffalo, New York, USA; Ophthalmology, State University of New York at Buffalo, Buffalo, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Karpinski","sequence":"additional","affiliation":[{"name":"Pediatric Multiple Sclerosis Center, State University of New York at Buffalo, Buffalo, New York, USA; Departments of Neurology, State University of New York at Buffalo, Buffalo, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Ramanathan","sequence":"additional","affiliation":[{"name":"Pediatric Multiple Sclerosis Center, State University of New York at Buffalo, Buffalo, New York, USA; Departments of Neurology, State University of New York at Buffalo, Buffalo, New York, USA; Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2009,5,22]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000133048.75452.dd"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000259422.44235.a8"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg045"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2003.10.056"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.59.7.1006"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(87)80454-7"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000036907.37650.8E"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2004.10.009"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2006.01.003"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(06)70573-7"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000259521.14704.a8"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.03-0514"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6702013"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000094315.19931.90"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20851"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20575"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2004.10.047"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000295995.46586.ae"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000260612.51849.ed"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2005.07.012"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2006.01.036"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1097\/00041327-199703000-00004"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2005.10.040"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2007.10.020"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.61.2.226"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.1191\/1352458504ms1098oa"},{"key":"atypb27","doi-asserted-by":"publisher","DOI":"10.1177\/1051228404266267"},{"key":"atypb28","doi-asserted-by":"publisher","DOI":"10.1097\/00006324-200304000-00009"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458509104586","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458509104586","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:26:02Z","timestamp":1777692362000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1352458509104586"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5,22]]},"references-count":28,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["10.1177\/1352458509104586"],"URL":"https:\/\/doi.org\/10.1177\/1352458509104586","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5,22]]}}}