{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:50:10Z","timestamp":1792443010436,"version":"4.5.0"},"reference-count":25,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2009,6,19]],"date-time":"2009-06-19T00:00:00Z","timestamp":1245369600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2009,7]]},"abstract":"<jats:p>Background<\/jats:p>\n                  <jats:p>Cerebellar dysfunction is common in patients with multiple sclerosis (MS). However, neuropsychological studies of this clinical feature are lacking.<\/jats:p>\n                  <jats:p>Objective<\/jats:p>\n                  <jats:p>We investigate the neuropsychological features in relapsing-remitting MS (RR-MS) patients with and without cerebellar dysfunction.<\/jats:p>\n                  <jats:p>Methods<\/jats:p>\n                  <jats:p>Twenty-one RR-MS patients with cerebellar dysfunction (RR-MSc), characterized by prevalent ataxic gait and nystagmus, and 21 RR-MS patients without any cerebellar manifestation (RR-MSnc) pair-matched for demographical and clinical variables were studied. All patients from each group underwent an extensive battery of neuropsychological tests. Magnetic resonance imaging analysis included hyperintense fast fluid-attenuated inversion-recovery lesion load in the whole brain as well as in the four lobes separately.<\/jats:p>\n                  <jats:p>Results<\/jats:p>\n                  <jats:p>Any significant differences were detected in total and regional lesion load measurements between the two groups. RR-MSc group performed equally as well as the RR-MSnc group on many of the cognitive exploration measures. Nevertheless, the RR-MSc group performed more poorly than the RR-MSnc group on attention tests (Symbol Digit Modalities Test) and verbal fluency tests (Controlled Oral Word Association Test); neither of the test results proved to be affected by regional lesion loads.<\/jats:p>\n                  <jats:p>Conclusion<\/jats:p>\n                  <jats:p>These results highlight the importance of considering cognitive deficits associated with the presence of cerebellar symptoms in RR-MS.<\/jats:p>","DOI":"10.1177\/1352458509104589","type":"journal-article","created":{"date-parts":[[2009,6,19]],"date-time":"2009-06-19T11:26:18Z","timestamp":1245410778000},"page":"854-859","source":"Crossref","is-referenced-by-count":48,"title":["Cognitive deficits in multiple sclerosis patients with cerebellar symptoms"],"prefix":"10.1177","volume":"15","author":[{"given":"P","family":"Valentino","sequence":"first","affiliation":[{"name":"Institute of Neurology, University Magna Graecia, Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Cerasa","sequence":"additional","affiliation":[{"name":"Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Cosenza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Chiriaco","sequence":"additional","affiliation":[{"name":"Institute of Neurology, University Magna Graecia, Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Nistic\u00f2","sequence":"additional","affiliation":[{"name":"Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Cosenza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Pirritano","sequence":"additional","affiliation":[{"name":"Institute of Neurology, University Magna Graecia, Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MC","family":"Gioia","sequence":"additional","affiliation":[{"name":"Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Cosenza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Lanza","sequence":"additional","affiliation":[{"name":"Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Cosenza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Canino","sequence":"additional","affiliation":[{"name":"Institute of Neurology, University Magna Graecia, Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Del Giudice","sequence":"additional","affiliation":[{"name":"Institute of Neurology, University Magna Graecia, Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Gallo","sequence":"additional","affiliation":[{"name":"Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Cosenza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Condino","sequence":"additional","affiliation":[{"name":"Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Cosenza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Torchia","sequence":"additional","affiliation":[{"name":"Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Cosenza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Quattrone","sequence":"additional","affiliation":[{"name":"Institute of Neurology, University Magna Graecia, Catanzaro, Italy; 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