{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:27:09Z","timestamp":1790857629954,"version":"4.1.0"},"reference-count":44,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2010,1,19]],"date-time":"2010-01-19T00:00:00Z","timestamp":1263859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:p>MRI brain lesions at presentation with optic neuritis (ON) increase the risk for developing clinically definite (CD) multiple sclerosis (MS). More detailed early MRI findings may improve prediction of conversion.<\/jats:p>\n                  <jats:p>The objectives of this study were to investigate the influence of number, location and activity of lesions at presentation, new lesions at early follow-up and non-lesion MRI measures on conversion from optic neuritis (ON) to CDMS.<\/jats:p>\n                  <jats:p>142\/143 ON patients, prospectively recruited into a serial MRI and clinical follow-up study, were followed-up at least once. Cox regression analysis determined independent early MRI predictors of time to CDMS from: (i) baseline lesion number, location and activity measures, (ii) three-month lesion activity measures and (iii) brain atrophy, magnetization transfer ratio and spectroscopy measures.<\/jats:p>\n                  <jats:p>114\/142 (80%) had abnormal baseline brain or cord MRI. 57 (40%) developed CDMS (median of 16 months from clinically isolated syndrome onset). Median follow-up of the non-converters was 62 months. Multivariate analysis of baseline parameters revealed gender, periventricular and gadolinium-enhancing lesions as independent predictors of CDMS. Considering both scans together, gender, baseline periventricular and new T2 lesions at follow-up remained significant (hazard ratios 2.1, 2.4 and 4.9, respectively). No non-conventional measure predicted CDMS.<\/jats:p>\n                  <jats:p>It was concluded that new T2 lesions on an early follow-up scan were the strongest independent predictor of CDMS.<\/jats:p>","DOI":"10.1177\/1352458509353650","type":"journal-article","created":{"date-parts":[[2010,1,19]],"date-time":"2010-01-19T20:47:20Z","timestamp":1263934040000},"page":"156-165","source":"Crossref","is-referenced-by-count":59,"title":["Early MRI in optic neuritis: the risk for clinically definite multiple sclerosis"],"prefix":"10.1177","volume":"16","author":[{"given":"JK","family":"Swanton","sequence":"first","affiliation":[{"name":"Department of Neuroinflammation and NMR Research Unit, UCL Institute of Neurology, London, UK,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KT","family":"Fernando","sequence":"additional","affiliation":[{"name":"Department of Neuroinflammation and NMR Research Unit, UCL Institute of Neurology, London, 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