{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T02:06:22Z","timestamp":1779242782003,"version":"3.51.4"},"reference-count":82,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2010,3,5]],"date-time":"2010-03-05T00:00:00Z","timestamp":1267747200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:p>Background: Multifocal visual evoked potentials (mfVEP) measure local response amplitude and latency in the field of vision.<\/jats:p>\n                  <jats:p>Objective: To compare the sensitivity of mfVEP, Humphrey visual field (HVF) and optical coherence tomography (OCT) in detecting visual abnormality in multiple sclerosis (MS) patients.<\/jats:p>\n                  <jats:p>Methods: mfVEP, HVF, and OCT (retinal nerve fiber layer [RNFL]) were performed in 47 MS-ON eyes (last optic neuritis [ON] attack \u22656 months prior) and 65 MS-no-ON eyes without ON history. Criteria to define an eye as abnormal were: (1) mfVEP amplitude\/latency \u2014 either amplitude or latency probability plots meeting cluster criteria with 95% specificity; (2) mfVEP amplitude or latency alone (specificity: 97% and 98%, respectively); and (3) HVF and OCT, mean deviation and RNFL thickness meeting p &lt; 0.05, respectively.<\/jats:p>\n                  <jats:p>Results: MfVEP (amplitude\/latency) identified more abnormality in MS-ON eyes (89%) than HVF (72%), OCT (62%), mfVEP amplitude (66%) or latency (67%) alone. Eighteen percent of MS-no-ON eyes were abnormal for both mfVEP (amplitude\/latency) and HVF compared with 8% with OCT. Agreement between tests ranged from 60% to 79%. mfVEP (amplitude\/latency) categorized an additional 15% of MS-ON eyes as abnormal compared with HVF and OCT combined. Conclusions: mfVEP, which detects both demyelination (increased latency) and neural degeneration (reduced amplitude), revealed more abnormality than HVF or OCT in MS patients.<\/jats:p>","DOI":"10.1177\/1352458509359782","type":"journal-article","created":{"date-parts":[[2010,3,5]],"date-time":"2010-03-05T21:41:06Z","timestamp":1267825266000},"page":"412-426","source":"Crossref","is-referenced-by-count":50,"title":["Comparison of multifocal visual evoked potential, standard automated perimetry and optical coherence tomography in assessing visual pathway in multiple sclerosis patients"],"prefix":"10.1177","volume":"16","author":[{"given":"Michal","family":"Laron","sequence":"first","affiliation":[{"name":"University of Houston, College of Optometry, Houston, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Han Cheng","sequence":"additional","affiliation":[{"name":"University of Houston, College of Optometry, Houston, Texas, USA,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Bin Zhang","sequence":"additional","affiliation":[{"name":"University of Houston, College of Optometry, Houston, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jade S","family":"Schiffman","sequence":"additional","affiliation":[{"name":"Section of Ophthalmology, Department of Head and Neck Surgery, University of Texas M. 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Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa A","family":"Tang","sequence":"additional","affiliation":[{"name":"University of Houston, MS Eye CARE Clinic, Houston, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura J","family":"Frishman","sequence":"additional","affiliation":[{"name":"University of Houston, College of Optometry, Houston, Texas, 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