{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:22:29Z","timestamp":1778631749483,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2010,1,19]],"date-time":"2010-01-19T00:00:00Z","timestamp":1263859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:p>The pathological effects of multiple sclerosis are not confined to lesions; tissues that appear normal on conventional magnetic resonance imaging scans are also affected, albeit subtly. One imaging technique that has proven sensitive to such effects is T1-relaxation time measurement, with previous work demonstrating abnormalities in normal-appearing white matter and grey matter. In this work we investigated the evolution of T1-relaxation time changes in normal-appearing white matter and grey matter in relapsing\u2014remitting multiple sclerosis. Three- and five-year follow-up data from 35 people with clinically early (a mean of 1.6 years from first clinical event) relapsing\u2014remitting multiple sclerosis and 15 healthy controls were analysed. T1-relaxation time histograms were extracted from normal-appearing white matter and grey matter, and mean, peak height and peak location values were estimated. T1-relaxation time peak height declined in the multiple sclerosis normal-appearing white matter and grey matter, but not the control group (rate difference p = 0.024 in normal-appearing white matter, in normal-appearing grey matter p = 0.038); other T1-relaxation time changes were not significantly different between groups. Changes in T1-relaxation time measures did not correlate with increases in brain T2-weighted lesion loads or Expanded Disability Status Scale scores. These results suggest that the processes underlying changes in normal-appearing white matter and grey matter T1-relaxation times are not immediately linked to white matter lesion formation, and may represent more diffuse but progressive sub-clinical pathology in relapsing\u2014remitting multiple sclerosis.<\/jats:p>","DOI":"10.1177\/1352458509359924","type":"journal-article","created":{"date-parts":[[2010,1,19]],"date-time":"2010-01-19T20:47:20Z","timestamp":1263934040000},"page":"427-433","source":"Crossref","is-referenced-by-count":27,"title":["TI-relaxation time changes over five years in relapsing-remitting multiple sclerosis"],"prefix":"10.1177","volume":"16","author":[{"given":"Konstantinos","family":"Papadopoulos","sequence":"first","affiliation":[{"name":"B Neurological Clinic, AHEPA University Hospital, Aristotle University of Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J","family":"Tozer","sequence":"additional","affiliation":[{"name":"MS NMR Research Unit, UCL Institute of Neurology, London, UK, Department of Neuroinflammation, UCL Institute of Neurology, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonora","family":"Fisniku","sequence":"additional","affiliation":[{"name":"MS NMR Research Unit, UCL Institute of Neurology, London, UK, Department of Neuroinflammation, UCL Institute of Neurology, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel R","family":"Altmann","sequence":"additional","affiliation":[{"name":"MS NMR Research Unit, UCL Institute of Neurology, London, UK, London School of Hygiene & Tropical Medicine, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerard","family":"Davies","sequence":"additional","affiliation":[{"name":"MS NMR Research Unit, UCL Institute of Neurology, London, UK, Department of Neuroinflammation, UCL Institute of Neurology, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waqar","family":"Rashid","sequence":"additional","affiliation":[{"name":"MS NMR Research Unit, UCL Institute of Neurology, London, UK, Department of Neuroinflammation, UCL Institute of Neurology, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan J","family":"Thompson","sequence":"additional","affiliation":[{"name":"MS NMR Research Unit, UCL Institute of Neurology, London, UK, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David H","family":"Miller","sequence":"additional","affiliation":[{"name":"MS NMR Research Unit, UCL Institute of Neurology, London, UK, Department of Neuroinflammation, UCL Institute of Neurology, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Declan T","family":"Chard","sequence":"additional","affiliation":[{"name":"MS NMR Research Unit, UCL Institute of Neurology, London, UK, Department of Neuroinflammation, UCL Institute of Neurology, London, UK,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,1,19]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1097\/00019052-200206000-00003"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm329"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000237354.10144.ec"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.61.9.1386"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.61.2.217"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-005-5004-5"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-006-0408-4"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2403050569"},{"key":"atypb9","first-page":"868","volume":"27","author":"Vrenken 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