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This paper is a review of osteoporosis in people with multiple sclerosis, looking at its prevalence, risk factors and possible mechanisms. We also review management guidelines for osteoporosis in the general population and use these to propose guidelines for osteoporosis management amongst multiple sclerosis patients. A number of studies have examined the incidence of reduced bone mineral density amongst people with multiple sclerosis; the majority provide convincing evidence that bone mineral density is significantly reduced in multiple sclerosis patients. The most significant risk factors appear to arise from the chronic disease process of multiple sclerosis and not from glucocorticoid use. There are currently no guidelines or consensus as how best to treat osteoporosis amongst multiple sclerosis patients despite their being at an increased risk. We propose an algorithm for the screening and treatment of osteoporosis in people with multiple sclerosis.<\/jats:p>","DOI":"10.1177\/1352458510368985","type":"journal-article","created":{"date-parts":[[2010,6,15]],"date-time":"2010-06-15T20:45:54Z","timestamp":1276634754000},"page":"1031-1043","source":"Crossref","is-referenced-by-count":78,"title":["Osteoporosis in multiple sclerosis"],"prefix":"10.1177","volume":"16","author":[{"given":"Andrew P","family":"Hearn","sequence":"first","affiliation":[{"name":"Kings College London, School of Medicine, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eli","family":"Silber","sequence":"additional","affiliation":[{"name":"Queen Elizabeth Hospital, Neurology, London, UK, Kings College Hospital, Neurology, London, UK,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,6,15]]},"reference":[{"key":"atypb1","unstructured":"Hauser SL, Goodin DS Multiple sclerosis and other dymelinating disorders. 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